Detection of human parvovirus B19 in papillary thyroid carcinoma.

Detection of human parvovirus B19 in papillary thyroid carcinoma. Research Abstract Details 

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Detection of human parvovirus B19 in papillary thyroid carcinoma. Abstract Text:

J H Wang,W P Zhang,H X Liu,D Wang,Y F Li,W Q Wang,L Wang,F R He,Z Wang,Q G Yan,L W Chen,G S Huang,J H Wang,W P Zhang,H X Liu,D Wang,Y F Li,W Q Wang,L Wang,F R He,Z Wang,Q G Yan,L W Chen,G S Huang,

To evaluate whether parvovirus B19, a common human pathogen, was also involved in papillary thyroid carcinoma (PTC), 112 paraffin-embedded thyroid specimens of benign nodules, papillary, medullary and follicular carcinomas, and normal controls were examined for B19 DNA and capsid protein by nested PCR, in situ hybridisation (ISH) and immunohistochemistry (IHC). The expression of the nuclear factor-kappaB (NF-kappaB) was investigated by IHC. The results showed B19 DNA commonly exists in human thyroid tissues; however, there were significant differences between PTC group and normal controls, and between PTC and nonneoplastic adjacent tissues (P<0.001). The presence of viral DNA in PTC neoplastic epithelium was confirmed by laser-capture microdissection and sequencing of nested PCR products. B19 capsid protein in PTC group was significantly higher than that of all the control groups and nonneoplastic adjacent tissues (P

Detection of human parvovirus B19 in papillary thyroid carcinoma. Publishing Authors By Initials

JH Wang,WP Zhang,HX Liu,D Wang,YF Li,WQ Wang,L Wang,FR He,Z Wang,QG Yan,LW Chen,GS Huang,JH Wang,WP Zhang,HX Liu,D Wang,YF Li,WQ Wang,L Wang,FR He,Z Wang,QG Yan,LW Chen,GS Huang,

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Detection of human parvovirus B19 in papillary thyroid carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of cancer

VOLUME: 98

Page Numbers: 611-8

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 22

MONTH: 01

YEAR: 2008

Detection of human parvovirus B19 in papillary thyroid carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 370635

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Grant and Affiliation Information for Detection of human parvovirus B19 in papillary thyroid carcinoma.

AFFILIATION: 1State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Country: England

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MEDLINETA: Br J Cancer

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