Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results.

Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Research Abstract Details 

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Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Abstract Text:

Renuka Lakshminarayanan,Yueju Li,Kim Janatpour,Laurel Beckett,Ishwarlal Jialal,

Serum protein electrophoresis (SPE) demonstrates a monoclonal protein as an M spike in the majority of patients with monoclonal gammopathies. However, in patients with an apparently normal SPE pattern or hypogammaglobulinemia, immunofixation electrophoresis (IFE) can reveal an M protein. We undertook this study to determine the yield of reflex IFE testing in patients with hypogammaglobulinemia and to identify any laboratory or biochemical parameters that would predict a positive IFE result. We evaluated 380 patients with hypogammaglobulinemia and a normal SPE pattern. Of 380, 37 (9.7%) had a positive IFE result in serum, urine, or both. Of the other laboratory values evaluated, a high alpha2-globulin level with an increased alpha2-globulin/alpha1-globulin ratio, a low hemoglobin level, and an elevated creatinine level predicted a positive IFE result. There was a 2-fold increase in the odds ratio for a positive IFE result when the alpha2-globulin/alpha1-globulin ratio was elevated. We recommend reflex IFE testing in patients with hypogammaglobulinemia with a normal SPE pattern if any of the following are present: elevated alpha2- globulin/alpha1-globulin ratio, low hemoglobin level, and elevated creatinine level.

Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Publishing Authors By Initials

R Lakshminarayanan,Y Li,K Janatpour,L Beckett,I Jialal,

For similar proteins: blood proteins: acute-phase proteins: alpha-macroglobulins research abstracts see: proteins: blood proteins: acute-phase proteins: alpha-macroglobulins research

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Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of clinical pathology

VOLUME: 127

Page Numbers: 746-51

Journal Abbreviation:

ISSN: 0002-9173

DAY: 3

MONTH: May

YEAR: 2007

Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370470

Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Keywords Mesh Terms:

KEYWORDS: alpha-Macroglobulins

MESH TERMS: analysis

Chemical & Substance for Abstract: Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Information

Substance Name: alpha-Macroglobulins

Registry Number: 0

Grant and Affiliation Information for Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of California, Davis, School of Medicine, CA, USA.

Country: United States

AGENCY: United States NCCAM

GRANT: K24AT00596

ACRONYM: AT

MEDLINETA: Am J Clin Pathol

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