Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact.

Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact. Research Abstract Details 

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Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact. Abstract Text:

Shuichi Mitsunaga,Takahiro Hasebe,Taira Kinoshita,Masaru Konishi,Shinichiro Takahashi,Naoto Gotohda,Toshio Nakagohri,Atsushi Ochiai,Shuichi Mitsunaga,Takahiro Hasebe,Taira Kinoshita,Masaru Konishi,Shinichiro Takahashi,Naoto Gotohda,Toshio Nakagohri,Atsushi Ochiai,

Nerve plexus invasion is regarded as one of the most important prognostic factors in invasive ductal carcinoma (IDC) of the pancreas, though nerve plexus invasion has not been evaluated in terms of prognostic impact on the basis of detailed histologic investigation. The purpose of this study was to precisely examine morphologic characteristics of nerve plexus invasion and analyze its prognostic predictive power compared with the well-known prognostic parameters of pancreatic IDCs. The outcome and histologic features of 75 patients with pancreatic IDC in the pancreas head were investigated, and 422 lesions of nerve plexus invasion were evaluated. Tumor cells invading nerve plexus showed a duct-forming differentiated feature and predominantly existed in the perineurium and perineural space. Multivariate analyses revealed that the important prognostic factors, in addition to invasive tumor size and tumor necrosis, were at long distances from nerve plexus invasion to pancreatic capsule and perineural invasion in nerve plexus invasion.

Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact. Publishing Authors By Initials

S Mitsunaga,T Hasebe,T Kinoshita,M Konishi,S Takahashi,N Gotohda,T Nakagohri,A Ochiai,S Mitsunaga,T Hasebe,T Kinoshita,M Konishi,S Takahashi,N Gotohda,T Nakagohri,A Ochiai,

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Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of surgical pathology

VOLUME: 31

Page Numbers: 1636-44

Journal Abbreviation: Am. J. Surg. Pathol.

ISSN: 0147-5185

DAY: 6

MONTH: Nov

YEAR: 2007

Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact. Information

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LANGUAGE: eng

NlmUniqueID: 7707904

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AFFILIATION: Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Country: United States

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MEDLINETA: Am J Surg Pathol

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