Destructive cycles: the role of genomic instability and adaptation in carcinogenesis.

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Research Abstract Details 

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Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Abstract Text:

Brandt L Schneider,Molly Kulesz-Martin,

Classical theories of carcinogenesis postulate that the accumulation of several somatic mutations is responsible for oncogenesis. However, these models do not explain how non-mutagenic carcinogens cause cancer. In addition, known mutation rates appear to be insufficient to account for observed cancer rates. Moreover, the current theory doesn't easily account for the long latencies observed in human cancers. Proponents of an aneuploidy-driven theory of carcinogenesis suggest that genomic instability has a causative role in carcinogenesis. In support of this theory, pre-neoplastic cells frequently display genomic instability while normal cells do not. Data obtained from a variety of model organisms have revealed that disruption of the cell cycle controls required for homeostasis results in the acquisition of genomic instability. Subsequently, this genomic instability becomes self-propagating via 'destructive cycles' and provides a medium for cellular selection and adaptation. Genomic instability allows numerous genetic and epigenetic alterations to accumulate during carcinogenesis without markedly changing phenotype until they are qualitatively or quantitatively sufficient to be selectively advantageous in the tumor microenvironment. Observations of adaptation in tumor cell populations and application of chaos theory may help elucidate the mechanism that drives the enormous genetic heterogeneity observed in tumors and provide insights into the development of new therapeutic cancer interventions and treatments.

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Publishing Authors By Initials

BL Schneider,M Kulesz-Martin,

For similar neoplasms research abstracts see: neoplasms research

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Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Carcinogenesis

VOLUME: 25

Page Numbers: 2033-44

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 3

MONTH: 06

YEAR: 2004

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Information

Number of References: 200

LANGUAGE: eng

NlmUniqueID: 8008055

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: genetics

Chemical & Substance for Abstract: Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Information

Substance Name: Carcinogens

Registry Number: 0

Grant and Affiliation Information for Destructive cycles: the role of genomic instability and adaptation in carcinogenesis.

AFFILIATION: Department of Cell Biology and Biochemistry, Room 5C119, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA. brandt.schneider@ttmc.ttuhsc.edu

Country: England

AGENCY: United States NCI

GRANT: CA98893

ACRONYM: CA

MEDLINETA: Carcinogenesis

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