Desorption/ionization on silicon nanowires.

Desorption/ionization on silicon nanowires. Research Abstract Details 

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Desorption/ionization on silicon nanowires. Abstract Text:

E P Go,J V Apon,G Luo,A Saghatelian,R H Daniels,V Sahi,R Dubrow,B F Cravatt,A Vertes,G Siuzdak,

Dense arrays of single-crystal silicon nanowires (SiNWs) have been used as a platform for laser desorption/ionization mass spectrometry of small molecules, peptides, protein digests, and endogenous and xenobiotic metabolites in biofluids. Sensitivity down to the attomole level has been achieved on the nanowire surfaces by optimizing laser energy, surface chemistry, nanowire diameter, length, and growth orientation. An interesting feature of the nanowire surface is that it requires lower laser energy as compared to porous silicon and MALDI to desorb/ionize small molecules, therefore reducing background ion interference. Taking advantage of their high surface area and fluid wicking capabilities, SiNWs were used to perform chromatographic separation followed by mass analysis of the separated molecules providing a unique platform that can integrate separation and mass spectrometric detection on a single surface.

Desorption/ionization on silicon nanowires. Publishing Authors By Initials

EP Go,JV Apon,G Luo,A Saghatelian,RH Daniels,V Sahi,R Dubrow,BF Cravatt,A Vertes,G Siuzdak,

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Desorption/ionization on silicon nanowires. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Analytical chemistry

VOLUME: 77

Page Numbers: 1641-6

Journal Abbreviation: Anal. Chem.

ISSN: 0003-2700

DAY: 15

MONTH: Mar

YEAR: 2005

Desorption/ionization on silicon nanowires. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370536

Desorption/ionization on silicon nanowires. Keywords Mesh Terms:

KEYWORDS: Spectrometry, Mass, Matrix-Assisted Lase

MESH TERMS: instrumentation

Chemical & Substance for Abstract: Desorption/ionization on silicon nanowires. Information

Substance Name: Silicon

Registry Number: 7440-21-3

Grant and Affiliation Information for Desorption/ionization on silicon nanowires.

AFFILIATION: Department of Molecular Biology and Center for Mass Spectrometry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM05775

ACRONYM: GM

MEDLINETA: Anal Chem

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