Designing a nanotube using naturally occurring protein building blocks.

Designing a nanotube using naturally occurring protein building blocks. Research Abstract Details 

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Designing a nanotube using naturally occurring protein building blocks. Abstract Text:

Chung-Jung Tsai,Jie Zheng,Ruth Nussinov,

Here our goal is to carry out nanotube design using naturally occurring protein building blocks. Inspection of the protein structural database reveals the richness of the conformations of proteins, their parts, and their chemistry. Given target functional protein nanotube geometry, our strategy involves scanning a library of candidate building blocks, combinatorially assembling them into the shape and testing its stability. Since self-assembly takes place on time scales not affordable for computations, here we propose a strategy for the very first step in protein nanotube design: we map the candidate building blocks onto a planar sheet and wrap the sheet around a cylinder with the target dimensions. We provide examples of three nanotubes, two peptide and one protein, in atomistic model detail for which there are experimental data. The nanotube models can be used to verify a nanostructure observed by low-resolution experiments, and to study the mechanism of tube formation.

Designing a nanotube using naturally occurring protein building blocks. Publishing Authors By Initials

CJ Tsai,J Zheng,R Nussinov,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Designing a nanotube using naturally occurring protein building blocks. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: PLoS computational biology

VOLUME: 2

Page Numbers: e42

Journal Abbreviation: PLoS Comput. Biol.

ISSN: 1553-7358

DAY: 28

MONTH: 04

YEAR: 2006

Designing a nanotube using naturally occurring protein building blocks. Information

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LANGUAGE: eng

NlmUniqueID: 101238922

Designing a nanotube using naturally occurring protein building blocks. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: chemistry

Chemical & Substance for Abstract: Designing a nanotube using naturally occurring protein building blocks. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Designing a nanotube using naturally occurring protein building blocks.

AFFILIATION: Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research, Nanobiology Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America.

Country: United States

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: PLoS Comput Biol

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