Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution.

Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution. Research Abstract Details 

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Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution. Abstract Text:

Bishnu Prasad Joshi,Won-Mi Cho,Jongseung Kim,Juyoung Yoon,Keun-Hyeung Lee,Bishnu Prasad Joshi,Won-Mi Cho,Jongseung Kim,Juyoung Yoon,Keun-Hyeung Lee,

A new fluorescent peptide probe for the detection of Zn(2+) was synthesized on the basis of zinc binding ligands in zinc enzymes. The peptide that has a unique amino acid sequence displayed a great selectivity for Zn(2+) in the presence of several transition metal ions in aqueous solution. The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied. Further, on-bead application of the peptide as chemosensors was demonstrated.

Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution. Publishing Authors By Initials

BP Joshi,WM Cho,J Kim,J Yoon,KH Lee,BP Joshi,WM Cho,J Kim,J Yoon,KH Lee,

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Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6425-9

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 5

MONTH: 10

YEAR: 2007

Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn(2+) in aqueous solution.

AFFILIATION: Department of Chemistry, Bioorganic Chemistry Laboratory, Inha University, Incheon 402-751, Republic of Korea.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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