Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.

Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Research Abstract Details 

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Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Abstract Text:

Wenge Zhong,Hu Liu,Matthew R Kaller,Charles Henley,Ella Magal,Thomas Nguyen,Timothy D Osslund,David Powers,Robert M Rzasa,Hui-Ling Wang,Weiya Wang,Xiaoling Xiong,Jiandong Zhang,Mark H Norman,

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation is implicated in a number of neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. Using active site homology modeling between CDK5 and CDK2, we explored several different chemical series of potent CDK5 inhibitors. In this report, we describe the design, synthesis, and CDK5 inhibitory activities of quinolin-2(1H)-one derivatives.

Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Publishing Authors By Initials

W Zhong,H Liu,MR Kaller,C Henley,E Magal,T Nguyen,TD Osslund,D Powers,RM Rzasa,HL Wang,W Wang,X Xiong,J Zhang,MH Norman,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5384-9

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 6

MONTH: 08

YEAR: 2007

Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Information

Substance Name: Cyclin-Dependent Kinase 5

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.

AFFILIATION: Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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