Design and synthesis of novel antibacterial peptide-resin conjugates.

Design and synthesis of novel antibacterial peptide-resin conjugates. Research Abstract Details 

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Design and synthesis of novel antibacterial peptide-resin conjugates. Abstract Text:

Won-Mi Cho,Bishnu Prasad Joshi,Hyeongjin Cho,Keun-Hyeung Lee,Won-Mi Cho,Bishnu Prasad Joshi,Hyeongjin Cho,Keun-Hyeung Lee,

We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide.

Design and synthesis of novel antibacterial peptide-resin conjugates. Publishing Authors By Initials

WM Cho,BP Joshi,H Cho,KH Lee,WM Cho,BP Joshi,H Cho,KH Lee,

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Design and synthesis of novel antibacterial peptide-resin conjugates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5772-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 28

MONTH: 08

YEAR: 2007

Design and synthesis of novel antibacterial peptide-resin conjugates. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Design and synthesis of novel antibacterial peptide-resin conjugates.

AFFILIATION: Bioorganic Chemistry Laboratory, Department of Chemistry, Inha University, 253 Younghyong-Dong, Nam-Gu, Inchon-City 402-751, South Korea.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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