Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Research Abstract Details 

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Abstract Text:

Jeffrey A Pfefferkorn,Yuntao Song,Kuai-Lin Sun,Steven R Miller,Bharat K Trivedi,Chulho Choi,Roderick J Sorenson,Larry D Bratton,Paul C Unangst,Scott D Larsen,Toni-Jo Poel,Xue-Min Cheng,Chitase Lee,Noe Erasga,Bruce Auerbach,Valerie Askew,Lisa Dillon,Jeffrey C Hanselman,Zhiwu Lin,Gina Lu,Andrew Robertson,Karl Olsen,Thomas Mertz,Catherine Sekerke,Alexander Pavlovsky,Melissa S Harris,Graeme Bainbridge,Nicole Caspers,Huifen Chen,Matthias Eberstadt,

This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Publishing Authors By Initials

JA Pfefferkorn,Y Song,KL Sun,SR Miller,BK Trivedi,C Choi,RJ Sorenson,LD Bratton,PC Unangst,SD Larsen,TJ Poel,XM Cheng,C Lee,N Erasga,B Auerbach,V Askew,L Dillon,JC Hanselman,Z Lin,G Lu,A Robertson,K Olsen,T Mertz,C Sekerke,A Pavlovsky,MS Harris,G Bainbridge,N Caspers,H Chen,M Eberstadt,

For similar organic chemicals: amides: sulfonamides research abstracts see: organic chemicals: amides: sulfonamides research

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4538-44

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 6

MONTH: 06

YEAR: 2007

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Keywords Mesh Terms:

KEYWORDS: Sulfonamides

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Information

Substance Name: rosuvastatin

Registry Number: 287714-41-4

Grant and Affiliation Information for Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

AFFILIATION: Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. jeffrey.a.pfefferkorn@pfizer.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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