Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Abstract Text:

Sokhom S Pin,Cen Xu,Ben A Bahr,Sokhom S Pin,Cen Xu,Ben A Bahr,

Calcitonin gene-related peptide (CGRP) is a highly potent vasodilator known to be involved in many physiological functions within the cardiovascular, gastrointestinal, immune, and nervous systems. This study assessed the desensitization of CGRP receptors by measuring agonist-mediated activation of adenylate cyclase in a model system employing human neuroblastoma-derived SK-N-MC cells. In these cells, we demonstrated that pre-incubation with CGRP (20 nM) induces a rapid desensitization of CGRP signaling (t(1/2)

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Publishing Authors By Initials

SS Pin,C Xu,BA Bahr,SS Pin,C Xu,BA Bahr,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmacology

VOLUME: 577

Page Numbers: 7-16

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 17

MONTH: 08

YEAR: 2007

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1254354

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.

AFFILIATION: Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, United States. sokhom.pin@bms.com

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells Related Publications

• 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.
• An apple a day ...
• Are scientific societies serving the needs of graduate and postdoctoral students?
• Biomechanical analysis of anterior cruciate ligament injury mechanisms: three-dimensional motion reconstruction from video sequences.
• Changes in liver cell elements during stimulated protein synthesis; a cytochemical study.
• Comment on "Critical Pathway for an Aggressive Diagnostic Strategy for Patients Who Present with Chest Pain, but Non-Diagnostic EKG to the Emergency Department".
• Commentary.
• Commentary.
• Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.
• Effect of Lifestyle Intervention Emphasizing Physical Activity on Risk Factors for Diabetes and Cardiovascular Disease among High-risk Individuals: 710: May 31 1:45 PM 2:00 PM.
• Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.
• Estimating 3D joint kinematics from video sequences of running and cutting maneuvers--assessing the accuracy of simple visual inspection.
• Excess postexercise oxygen consumption--magnitude, mechanisms and practical implications.
• Excitotoxic protection by polyanionic polysaccharide: evidence of a cell survival pathway involving AMPA receptor-MAPK Interactions.
• Gephyrin Alterations Due to Protein Accumulation Stress are Reduced by the Lysosomal Modulator Z-Phe-Ala-Diazomethylketone.
• Hydrothaea irritans Fallén as a carrier of infection.
• Injuries in Norwegian female elite soccer: a prospective one-season cohort study.
• Mechanisms of anterior cruciate ligament injury in basketball: video analysis of 39 cases.
• Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience.
• Penetration rates of osmium tetroxide with different fixation vehicles.
• Prevention of hamstring strains in elite soccer: an intervention study.
• Prodromal symptom recognition of a heart attack: an overlooked phenomenon for recognizing a window of opportunity for early heart attack care.
• Race and nutrition: an investigation of Black-White differences in health-related nutritional behaviours.
• Surface plasmon resonance study of the spreading of a liquid-crystal smectic- a droplet on a gold substrate.
• Surface triple points and multiple-layer transitions observed by tuning the surface field at smectic liquid-crystal-water interfaces.
• Vaccination against the avian infectious bronchitis virus affects sperm concentration, sperm quality and blood testosterone concentrations in cockerels.
• What is your diagnosis?
• What is your diagnosis? Sialoliths.
• [Laser Doppler: new diagnostic possibilities in gestosis]
• [Piroxicam, a new non-steroid antirheumatic agent. Results of a multicentric study]