Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation.

Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Research Abstract Details 

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Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Abstract Text:

Guido Boerrigter,Lisa C Costello-Boerrigter,Gail J Harty,Harald Lapp,John C Burnett,

Brain natriuretic peptide (BNP 1-32) plays an important physiologic role in cardiorenal homeostasis. Recently, it has been reported that BNP 1-32 is rapidly cleaved by the ubiquitous enzyme dipeptidyl peptidase IV to BNP 3-32, which lacks the two NH2-terminal amino acids of BNP 1-32. The bioactivity of BNP 3-32 in cardiorenal regulation is unknown. We hypothesized that BNP 3-32 has reduced vasodilating and natriuretic bioactivity compared with BNP 1-32 in vivo. Synthetic human BNP 3-32 and BNP 1-32 were administered to eight anesthetized normal canines. After baseline measurements, BNP 1-32 at 30 ng x kg(-1) x min(-1) was administered, followed by a washout, a postinfusion clearance, and a clearance with an equimolar dose of BNP 3-32. In four studies, the sequence of BNP 1-32 and BNP 3-32 infusion was reversed. Peptides were compared by analyzing the changes from the respective preinfusion clearance to the respective infusion clearance. *P < 0.05 between peptides. BNP 3-32, unlike BNP 1-32, did not decrease mean arterial pressure (0 +/- 1 vs. -7 +/- 2* mmHg, respectively) and did not increase renal blood flow (+12 +/- 10 vs. +52 +/- 10* ml/min). Effects on heart rate and cardiac output were similar. Urinary sodium excretion increased 128 +/- 18 microeq/min with BNP 3-32 and 338 +/- 40* microeq/min with BNP 1-32. Urine flow increased 1.1 +/- 0.2 ml/min with BNP 3-32 and 2.8 +/- 0.4* ml/min with BNP 1-32. Plasma BNP immunoreactivity was lower with BNP 3-32, suggesting accelerated degradation. In this study, BNP 3-32 showed reduced natriuresis and diuresis and a lack of vasodilating actions compared with BNP 1-32.

Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Publishing Authors By Initials

G Boerrigter,LC Costello-Boerrigter,GJ Harty,H Lapp,JC Burnett,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research

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Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Regulatory, integr

VOLUME: 292

Page Numbers: R897-901

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 26

MONTH: 10

YEAR: 2006

Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Keywords Mesh Terms:

KEYWORDS: Water-Electrolyte Balance

MESH TERMS: physiology

Chemical & Substance for Abstract: Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation. Information

Substance Name: Antigens, CD26

Registry Number: EC 3.4.14.5

Grant and Affiliation Information for Des-serine-proline brain natriuretic peptide 3-32 in cardiorenal regulation.

AFFILIATION: Cardiorenal Research Laboratory, Guggenheim 915, Mayo Clinic and Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905, USA. boerrigter.guido@mayo.edu

Country: United States

AGENCY: United States NHLBI

GRANT: P01-HL-07111

ACRONYM: HL

MEDLINETA: Am J Physiol Regul Integr Comp

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