Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model.

Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Research Abstract Details 

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Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Abstract Text:

Wei Zhang,Charles S Chung, ,

Huxley's crossbridge attachment model predicts tension (contractile force) development in isometric (fixed length) cells using constant attachment and detachment rates. Alternative models incorporating time-varying calcium concentrations are complex (coupled linear differential equations) and use time-dependent inputs (calcium, elastance, etc.) to model multiple states. We hypothesize that by incorporating the known significant rise and fall in intracellular calcium, via either an asymmetric damped function or a symmetric Gaussian function, into a time-varying, rather than constant, attachment rate function, the Huxley model prediction for tension (i.e., chamber pressure) in isovolumic (isometric) non-ejecting beats will improve. To test the hypothesis that the time-dependent model-predicted (TDM) pressure fits the in vivo isometric (isovolumic) LV pressure phase-plane (PPP) contour better than the constant attachment rate predicted pressure, we used the TDM to fit non-ejecting, premature ventricular contraction (PVC) PPP contours in 6 subjects. Conventional model fit was poor (relative error 74.0%+/-12.5%), while the asymmetric damped TDM rate function provided slight improvement relative to the conventional time-independent model (relative error 55.4%+/-9.8%). The symmetric Gaussian rate function TDM provided the best PPP fit to all non-ejecting beats tested (relative error 19.8%+/-4.8%). We conclude that approximating the lumped attachment rate via a time-varying, rather than constant, rate function generates a physiologically viable model of crossbridge behavior. The PPP provides the optimal arena for alternate mathematical formulation assessment of LVP contour prediction by time-dependent attachment rate functions and facilitates modeling of cardiac contraction and relaxation.

Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Publishing Authors By Initials

W Zhang,CS Chung,SJ ,

For similar musculoskeletal system: muscles: muscle fibers: myofibrils: sarcomeres research abstracts see: musculoskeletal system: muscles: muscle fibers: myofibrils: sarcomeres research

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Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Cardiovascular engineering (Dordrecht, Netherlands

VOLUME: 6

Page Numbers: 132-44

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ISSN: 1567-8822

DAY: 3

MONTH: Dec

YEAR: 2006

Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Information

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LANGUAGE: eng

NlmUniqueID: 101132083

Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Keywords Mesh Terms:

KEYWORDS: Sarcomeres

MESH TERMS: physiology

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Grant and Affiliation Information for Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model.

AFFILIATION: Cardiovascular Biophysics Laboratory, Cardiovascular Division, Washington University School of Medicine, 660 South Euclid Ave, Box 8086, St. Louis, MO 63110, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: HL54179

ACRONYM: HL

MEDLINETA: Cardiovasc Eng

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