Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Abstract Text:

Suzanne Schubbert,Gideon Bollag,Kevin Shannon,

Ras proteins regulate cell proliferation, survival and differentiation and are constitutively activated by somatic point mutations in many cancers. Previous studies of neurofibromatosis type 1 and Noonan syndrome also implicated hyperactive Ras in developmental disorders. Recently, germline mutations in H-RAS and K-RAS and in genes encoding other molecules in the Ras-Raf-MEK-ERK cascade were shown to underlie cases of Noonan, cardio-facio-cutaneous, and Costello syndromes. These disorders share phenotypic traits that include abnormal facial features, heart defects, and impaired growth and development. Many of these germline, disease-associated mutations encode novel Ras, Raf and MEK proteins. These studies underscore a crucial role of Ras signaling in human development.

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Publishing Authors By Initials

S Schubbert,G Bollag,K Shannon,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ras proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ras proteins research

PUBMED ID PMID:

MEDLINE DATE:

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in genetics & development

VOLUME: 17

Page Numbers: 15-22

Journal Abbreviation: Curr. Opin. Genet. Dev.

ISSN: 0959-437X

DAY: 3

MONTH: Feb

YEAR: 2007

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Information

Number of References: 47

LANGUAGE: eng

NlmUniqueID: 9111375

Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Keywords Mesh Terms:

KEYWORDS: ras Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Information

Substance Name: ras Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

AFFILIATION: Department of Pediatrics, University of California, 513 Parnassus Avenue, Room HSE-302, San Francisco, CA 94143, USA.

Country: England

AGENCY: United States NCI

GRANT: R01 CA72614

ACRONYM: CA

MEDLINETA: Curr Opin Genet Dev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Deregulated Ras signaling in developmental disorders: new tricks for an old dog Related Publications

• A 6-item brief measure for assessing perceived control of asthma in culturally diverse patients.
• A conceptual application of health behavior theory in the design and implementation of a successful surgical weight loss program.
• A diruthenium-substituted polyoxometalate as an electrocatalyst for oxygen generation.
• Achieving form and function for Class II restorations: a simplified technique.
• Aflatoxins B1, B2, G1, and G2: separation and purification.
• Aging is associated with myocardial insulin resistance and mitochondrial dysfunction.
• Apparatus for measuring the finite load-deformation behavior of a sheet of epithelial cells cultured on a mesoscopic freestanding elastomer membrane.
• Asthma burden in a citywide, diverse sample of elementary schoolchildren in Chicago.
• Biochemical and functional characterization of germ line KRAS mutations.
• Case holding in out-patient therapy of syphilis; a study of case-holding experiences in the out-patient management of patients treated with penicillin on an ambulatory basis.
• Combined effects of frequency compression-expansion and shift on speech recognition.
• Deregulated Ras signaling in developmental disorders: new tricks for an old dog.
• Development and validation of the maximal electro-shock seizure model in dogs.
• Did you get an 'A'?
• Does time of measurement effect peak blood lactate following maximal exercise?: 1604: board #94 may 30 2:00 PM - 3:30 PM.
• Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
• Emergency care for children in pediatric and general emergency departments.
• Hereditary hemorrhagic telangiectasia and rutin.
• Improving medication compliance in patients with heart failure.
• Linking calsequestrin to lumenal control of SR Ca2+ release.
• Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy.
• Natural history of acoustic neuromas.
• Nutritional aspects of child and adolescent psychopharmacology.
• Patterns of workplace harassment, gender, and use of services: an update.
• Retinoblastoma, retinal glioma, cured by radon seeds; report of a case.
• Risky sexual behavior among women with protective orders against violent male partners.
• THE EFFECT OF EXPOSING STANNOUS FLUORIDE-TREATED ENAMEL SURFACES TO WHOLE SALIVA.
• Targeting oncogenic Ras.
• The establishment of health maintenance organizations: a geographical analysis.
• Tubulovillous adenoma of the prostatic urethra: a rare and usually indolent lesion distinct from prostatic adenocarcinoma.