Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development.

Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Research Abstract Details 

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Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Abstract Text:

We have postulated that the brain alterations observed after "in utero" alcohol exposure could be due, in part, to a direct effect of ethanol on astrogliogenesis. In the present work we summarize the main findings concerning the effect of prenatal exposure to alcohol on astrocytes in primary culture. We have found that this treatment alters astrocyte growth and the content and synthesis of DNA and proteins. However, "in utero" exposure to ethanol also causes important alterations in the astrocyte cytoskeleton which could be related to an alteration in the amount and activity of several plasma membrane glycoproteins. These results agree with ones obtained "in vivo" and suggest that ethanol-induced alterations in astrogliogenesis could be an important mechanism underlying the CNS disfunctions observed after prenatal exposure to ethanol.

Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Publishing Authors By Initials

For similar proteins: nerve tissue proteins research abstracts see: proteins: nerve tissue proteins research

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Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Journal Published:

PUBLICATION TYPE: Review

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 2

Page Numbers: 203-8

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1993

Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 8804836

Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Keywords Mesh Terms:

KEYWORDS: Nerve Tissue Proteins

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Derangement of astrogliogenesis as a possible mechanism involved in alcohol-induced alterations of central nervous system development.

AFFILIATION: Inst. Investigaciones Citológicas, Valencia, Spain.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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