Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement.

Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement. Research Abstract Details 

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Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement. Abstract Text:

Daisuke Katsumata,Hirokazu Fukui,Yuko Ono,Kazuhito Ichikawa,Shigeki Tomita,Johji Imura,Akihito Abe,Masanori Fujita,Osamu Watanabe,Masahiro Tsubaki,Masakatsu Sunagawa,Takahiro Fujimori,

PURPOSE: The relationship between the prognosis and the extent of colorectal carcinoma (CRC) is still unclear. As a simple parameter of the local invasion of CRC, we assessed the extent of tumor invasion beyond the outer border of the muscularis propria (MP). METHODS: We examined 147 cases of CRC using a slight modification of the procedure established by the Japanese Society for Cancer of the Colon and Rectum. For the statistical analysis, the patients were divided into two groups, namely, a "shallow" group and a "deep" group, using a specific cut-off value (COV). A multivariate analysis to identify independent prognostic factors was performed. RESULTS: Significant differences in the 5-year survival rate were observed between the "shallow" and "deep" groups in 39 cases of rectal carcinoma (COV 4 mm; 72.4% vs. 30.0%, hazard ratio = 3.204), but not observed in 147 cases of CRC. In addition, the outcome for patients with "deep" cancer in the lower rectum was markedly worse than that for patients with "shallow" cancer (COV 4 mm; 81.8% vs. 12.5%, hazard ratio = 5.371). CONCLUSIONS: The depth of tumor invasion beyond the MP is thus considered to be an important prognostic factor for patients with T3/T4 rectal carcinoma, especially in the lower rectum. A careful follow-up is required for the patients with rectal carcinoma that has invaded more than 4 mm beyond the MP.

Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement. Publishing Authors By Initials

D Katsumata,H Fukui,Y Ono,K Ichikawa,S Tomita,J Imura,A Abe,M Fujita,O Watanabe,M Tsubaki,M Sunagawa,T Fujimori,

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Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Surgery today

VOLUME: 38

Page Numbers: 115-22

Journal Abbreviation: Surg. Today

ISSN: 0941-1291

DAY: 1

MONTH: 02

YEAR: 2008

Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: The usefulness of elastic stain for its measurement. Information

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LANGUAGE: eng

NlmUniqueID: 9204360

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AFFILIATION: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan.

Country: Japan

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MEDLINETA: Surg Today

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