Depressive symptoms and the risk of incident delirium in older hospitalized adults.

Depressive symptoms and the risk of incident delirium in older hospitalized adults. Research Abstract Details 

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Depressive symptoms and the risk of incident delirium in older hospitalized adults. Abstract Text:

Gail J McAvay,Peter H Van Ness,Sidney T Bogardus,Ying Zhang,Douglas L Leslie,Linda S Leo-Summers,Sharon K Inouye,

OBJECTIVES: To determine whether specific subsets of symptoms from the Geriatric Depression Scale (GDS), assessed at hospital admission, were associated with the incidence of delirium. DESIGN: Secondary analysis of a prospective cohort study of patients from the Delirium Prevention Trial. SETTING: General medicine service at Yale New Haven Hospital, March 25, 1995, through March 18, 1998. PARTICIPANTS: Four hundred sixteen patients aged 70 and older who were at intermediate or high risk for delirium and were not taking antidepressants at hospital admission. MEASUREMENTS: Depressive symptoms were assessed GDS, and daily assessments of delirium were obtained using the Confusion Assessment Method. RESULTS: Of the 416 patients in the analysis sample, 36 (8.6%) developed delirium within the first 5 days of hospitalization. Patients who developed delirium reported 5.7 depressive symptoms on average, whereas patients without delirium reported an average of 4.2 symptoms. Using a Cox proportional hazards model, it was found that depressive symptoms assessing dysphoric mood and hopelessness were predictive of incident delirium, controlling for measures of physical and mental health. In contrast, symptoms of withdrawal, apathy, and vigor were not significantly associated with delirium. CONCLUSION: These findings suggest that assessing symptoms of dysphoric mood and hopelessness could help identify patients at risk for incident delirium. Future studies should evaluate whether nonpharmacological treatment for these symptoms reduces the risk of delirium.

Depressive symptoms and the risk of incident delirium in older hospitalized adults. Publishing Authors By Initials

GJ McAvay,PH Van Ness,ST Bogardus,Y Zhang,DL Leslie,LS Leo-Summers,SK Inouye,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Depressive symptoms and the risk of incident delirium in older hospitalized adults. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Geriatrics Society

VOLUME: 55

Page Numbers: 684-91

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ISSN: 0002-8614

DAY: 3

MONTH: May

YEAR: 2007

Depressive symptoms and the risk of incident delirium in older hospitalized adults. Information

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LANGUAGE: eng

NlmUniqueID: 7503062

Depressive symptoms and the risk of incident delirium in older hospitalized adults. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: psychology

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Grant and Affiliation Information for Depressive symptoms and the risk of incident delirium in older hospitalized adults.

AFFILIATION: Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. Gail.McAvay@yale.edu

Country: United States

AGENCY: United States NIA

GRANT: R21AG025193

ACRONYM: AG

MEDLINETA: J Am Geriatr Soc

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