Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis.

Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Research Abstract Details 

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Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Abstract Text:

Sherita Hill Golden,Hochang Benjamin Lee,Pamela J Schreiner,Ana Diez Roux,Annette L Fitzpatrick,Moyses Szklo,Constantine Lyketsos,

OBJECTIVE: To assess the cross-sectional association between depression and glucose tolerance status. METHODS: We conducted a study of 6754 White, Black, Hispanic, and Chinese men and women aged 45 to 84 years in the Multiethnic Study of Atherosclerosis (MESA). Depression was defined as Center for Epidemiologic Studies Depression scale score of > or =16 and/or antidepressant use. Glucose tolerance status was defined as normal, impaired fasting glucose (IFG) or Type 2 diabetes mellitus (untreated and treated). RESULTS: In the minimally adjusted model, although depression was not associated with a greater odds of IFG (odds ratio (OR) = 1.01; 95% confidence interval (CI): 0.87-1.18) or untreated diabetes (OR = 1.03; 95% CI: 0.74-1.45), it was associated with a greater odds of treated diabetes (OR = 1.57; 95% CI: 1.27-1.96). This persisted following adjustment for body mass index (OR = 1.52; 95% CI: 1.22-1.90), metabolic (OR = 1.54; 95% CI: 1.23-1.93), and inflammatory (OR=1.53; 95% CI: 1.21-1.92) factors, daily caloric intake and smoking (OR = 1.48; 95% CI: 1.16-1.88), and socioeconomic markers (OR = 1.47; 95% CI: 1.17-1.85). Among individuals with treated diabetes, median depression scores were higher in those with microalbuminuria compared with those without microalbuminuria (median = 7; interquartile range: 3-13 versus median = 6; interquartile range: 2-11; p = .046). Depression scores were not associated with homeostatic model assessment of insulin resistance among individuals without diabetes. CONCLUSIONS: In MESA, depression was significantly associated with treated diabetes. Further studies are needed to determine the temporality of this association.

Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Publishing Authors By Initials

SH Golden,HB Lee,PJ Schreiner,AD Roux,AL Fitzpatrick,M Szklo,C Lyketsos,

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PUBMED ID PMID:

MEDLINE DATE: 2007 Jul-Aug

Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychosomatic medicine

VOLUME: 69

Page Numbers: 529-36

Journal Abbreviation:

ISSN: 1534-7796

DAY: 16

MONTH: 07

YEAR: 2007

Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376505

Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosis.

AFFILIATION: Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. sahill@jhmi.edu

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-95169

ACRONYM: HC

MEDLINETA: Psychosom Med

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