Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta.

Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Research Abstract Details 

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Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Abstract Text:

M MacDougall,

Dentin phosphoprotein (DPP, phosphophoryn) is the major non-collagenous protein component of the dentin extracellular matrix. This highly acidic phosphorylated protein is solely expressed by ectomesenchymal-derived odontoblast cells of the tooth organ. Previous biochemical studies have suggested the absence of this protein associated with the human genetic disease dentinogenesis imperfecta (DGI) Types I and II. However, due to the normal degradation of human DPP during dentin maturation, it has not been possible to establish if these reported differences were due to changes in DPP expression or secondary degradation rates in DGI affected versus normal teeth. Recently, we have taken both a molecular and biochemical approach to address this problem. Molecular studies have utilized genetic linkage studies performed on several multi-generation informative DGI kindreds. These studies have determined linkage between DGI Types II and III and two markers localized to the long arm of human chromosome 4 in the region 4q11-4q21. The strategy used in our study was to map the DPP gene locus to the long arm of human chromosome 4, in the same region as DGI, using a DPP oligonucleotide probe and somatic hybrid cell lines. The results indicate DPP is not localized to any region of human chromosome 4. Our data indicates that a mutation within the DPP gene locus is not associated with DGI Types II or III. This data is supported by the identification of human DPP (95 kDa) within the dentin extracellular matrix of molars isolated from an affected DGI type II patient using a mouse anti-DPP antibody. However, this does not exclude the possibility that enzymes associated with DPP post-translational modifications (ie. phosphorylation or degradation) might be responsible for this genetic disease.

Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Publishing Authors By Initials

M MacDougall,

For similar proteins: phosphoproteins research abstracts see: proteins: phosphoproteins research

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Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Journal Published:

PUBLICATION TYPE: Review

Journal: Proceedings of the Finnish Dental Society. Suomen

VOLUME: 88 Suppl 1

Page Numbers: 195-208

Journal Abbreviation:

ISSN: 0355-4651

DAY: 21

MONTH: 02

YEAR: 1992

Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Information

Number of References: 61

LANGUAGE: eng

NlmUniqueID: 366632

Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Keywords Mesh Terms:

KEYWORDS: Phosphoproteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta. Information

Substance Name: phosphophoryn

Registry Number: 0

Grant and Affiliation Information for Dentin phosphoprotein in dentin development: implications in dentinogenesis imperfecta.

AFFILIATION: Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles.

Country: FINLAND

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MEDLINETA: Proc Finn Dent Soc

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