Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation.

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Abstract Text:

Min H Cho,Xiaohua Cao,Deheng Wang,Joe Z Tsien,

Although the functions of alpha-Ca(2+)/calmodulin-dependent kinase II (CaMKII) have been studied extensively, the role of betaCaMKII, a coconstituent of the CaMKII holoenzyme in synaptic plasticity, learning, and memory has not been examined in vivo. Here we produce a transgenic mouse line in which the inducible and reversible manipulation of betaCaMKII activity is restricted to the hippocampal dentate gyrus, the region where long-term potentiation was originally discovered. We demonstrate that betaCaMKII activity in the dentate gyrus selectively impaired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral pathway. Although the transgenic mice showed normal 1-day memories, they were severely impaired in 10-day contextual fear memory. Systematic manipulations of dentate betaCaMKII activity during various distinct memory stages further reveal the initial day within the postlearning consolidation period as a critical time window that is highly sensitive to changes in betaCaMKII activity. This study provides evidence not only for the functional role of betaCaMKII in the dentate gyrus plasticity and hippocampal memory, but also for the notion that the mismatch between the actual learning pattern and reactivation patterns in the dentate gyrus circuit can underlie long-term memory consolidation.

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Publishing Authors By Initials

MH Cho,X Cao,D Wang,JZ Tsien,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 16317-22

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 3

MONTH: 10

YEAR: 2007

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation.

AFFILIATION: Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation Related Publications

• A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure.
• Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo.
• Aptamers switch on fluorescence of triphenylmethane dyes.
• Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.
• Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation.
• Evolution of new nonantibody proteins via iterative somatic hypermutation.
• Evolving proteins in mammalian cells using somatic hypermutation.
• Fluorescence ratio imaging of dynamic intracellular signals.
• From the Cover: A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals.
• Functional disturbances in the striatum by region-specific ablation of NMDA receptors.
• Improving the photostability of bright monomeric orange and red fluorescent proteins.
• Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
• Maintenance of superior learning and memory function in NR2B transgenic mice during ageing.
• Measuring calcium signaling using genetically targetable fluorescent indicators.
• Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters.
• Preparation of the membrane-permeant biarsenicals FlAsH-EDT(2) and ReAsH-EDT(2) for fluorescent labeling of tetracysteine-tagged proteins.
• Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles.
• Real-time neural coding of memory.
• Roger Tsien: bringing color to cell biology. A passion for chemistry, color, and conversations with cells is what drives Roger Tsien. Interview by Ruth Williams.
• Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
• The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels.
• The sequence of events that underlie quantal transmission at central glutamatergic synapses.
• [FETAL ERYTHROCYTES AND HEMOGLOBIN IN INFANTS AND CHILDREN--INFLUENCE OF EXCHANGE TRANSFUSION.]