Density of perfused brain capillaries in the aged rat during the wake-sleep cycle.

Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Research Abstract Details 

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Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Abstract Text:

G Zoccoli,M L Lucchi,E Andreoli,P Lenzi,C Franzini,

Structural and functional age-related changes in brain vasculature might affect the cerebral microcirculation. The present study evaluated the density of perfused brain capillaries and the perfusion fraction (perfused/existing capillaries) in aged rats (24 months) during the states of the wake-sleep cycle (quiet wakefulness, quiet sleep, active sleep) characterized by different levels of brain activation. The number of perfused capillaries was determined by intravascular injection of the fluorescent marker Evans Blue; histochemical staining of the capillary endothelium identified the alkaline-phosphatase (AP) reactive quota of the anatomical population. No sleep-related changes in perfused capillary density were found, and the perfusion fraction in the AP-stained sub-population was high and stable (95%) across the sleep-wake cycle: changing levels of brain activation during sleep do not affect functional capillary density in aged rats.

Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Publishing Authors By Initials

G Zoccoli,ML Lucchi,E Andreoli,P Lenzi,C Franzini,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 130

Page Numbers: 73-7

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: Jan

YEAR: 2000

Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

Chemical & Substance for Abstract: Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Information

Substance Name: Evans Blue

Registry Number: 314-13-6

Grant and Affiliation Information for Density of perfused brain capillaries in the aged rat during the wake-sleep cycle.

AFFILIATION: Dipartimento di Fisiologia Umana e Generale, Università degli Studi di Bologna, Italy.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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