Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity.

Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Research Abstract Details 

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Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Abstract Text:

Kampa,Johannes J Letzkus,Greg J Stuart,

The ability of neurons to modulate the strength of their synaptic connections has been shown to depend on the relative timing of pre- and postsynaptic action potentials. This form of synaptic plasticity, called spike-timing-dependent plasticity (STDP), has become an attractive model for learning at the single-cell level. Yet, despite its popularity in experimental and theoretical neuroscience, the influence of dendritic mechanisms in the induction of STDP has been largely overlooked. Several recent studies have investigated how active dendritic properties and synapse location within the dendritic tree influence STDP. These studies suggest the existence of learning rules that depend on firing mode and subcellular input location, adding unanticipated complexity to STDP. Here, we propose a new look at STDP that is focused on processing at the postsynaptic site in the dendrites, rather than on spike-timing at the cell body.

Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Publishing Authors By Initials

BM Kampa,JJ Letzkus,GJ Stuart,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in neurosciences

VOLUME: 30

Page Numbers: 456-63

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 31

MONTH: 08

YEAR: 2007

Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Information

Number of References: 69

LANGUAGE: eng

NlmUniqueID: 7808616

Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

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Grant and Affiliation Information for Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity.

AFFILIATION: Brain Research Institute, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland. kampa@hifo.unizh.ch

Country: England

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MEDLINETA: Trends Neurosci

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