Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity.

Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Research Abstract Details 

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Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Abstract Text:

Liposomes represent a promising vehicle to deliver exogenous antigens to dendritic cells (DCs) for tumor immunotherapy. Targeting exogenous antigens to Fcgamma receptors on DCs has been shown to result in efficient presentation of antigen-derived peptides on major histocompatibility complex (MHC) class I and class II molecules. In this study, it was investigated whether DCs that endocytosed physicochemically optimized antigen-containing liposomes conjugated with IgG efficiently present antigens on MHC class I and class II molecules, and consequently induce strong antitumor immune responses. IgG-conjugated liposomes that were 200 nm in diameter without attaching polyethylene glycol were most efficiently endocytosed by DCs. Human monocyte-derived DCs that endocytosed tetanus toxoid (TT)-containing IgG liposomes via CD32 stimulated CD4(+) T cells more strongly than DCs pulsed with TT-containing bare liposomes or with soluble TT. Immunization of mice with DCs that endocytosed ovalbumin (OVA)-containing IgG liposomes but not OVA-containing bare liposomes or soluble OVA completely prevented the growth of OVA-expressing lymphoma cells. Importantly, administration of DCs that endocytosed OVA-containing IgG liposomes to the mice with established OVA-expressing tumors strongly suppressed tumor growth. This study demonstrates an IgG liposome with physicochemical properties suitable for delivering antigens to DCs and paves the way to the application of IgG liposomes for tumor immunotherapy using DCs.

Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Publishing Authors By Initials

For similar neoplasms research abstracts see: neoplasms research

PUBMED ID PMID:

MEDLINE DATE: 2006 Mar-Apr

Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997)

VOLUME: 29

Page Numbers: 165-74

Journal Abbreviation: J. Immunother.

ISSN: 1524-9557

DAY: 18

MONTH: 03

YEAR: 2008

Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9706083

Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: therapy

Chemical & Substance for Abstract: Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. Information

Substance Name: Liposomes

Registry Number: 0

Grant and Affiliation Information for Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity.

AFFILIATION: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Country: United States

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MEDLINETA: J Immunother

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