Dendritic cells in asthma and COPD: opportunities for drug development.

Dendritic cells in asthma and COPD: opportunities for drug development. Research Abstract Details 

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Dendritic cells in asthma and COPD: opportunities for drug development. Abstract Text:

Mirjam Kool,Bart N Lambrecht,Mirjam Kool,Bart N Lambrecht,

The lung contains many subsets of dendritic cells that are distributed in various anatomical compartments. In homeostatic conditions, a fine-tuned balance exists between plasmacytoid and myeloid dendritic cells necessary for maintaining tolerance to inhaled antigen and avoiding overt inflammation. These subsets of DCs also play important roles in establishment of airway inflammation seen in asthma and chronic obstructive pulmonary disease. Based on these new insights on airway DC biology, several approaches that interfere with DC function show potential as new intervention strategies for these ever increasing diseases.

Dendritic cells in asthma and COPD: opportunities for drug development. Publishing Authors By Initials

M Kool,BN Lambrecht,M Kool,BN Lambrecht,

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Dendritic cells in asthma and COPD: opportunities for drug development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in immunology

VOLUME: 19

Page Numbers: 701-10

Journal Abbreviation: Curr. Opin. Immunol.

ISSN: 0952-7915

DAY: 30

MONTH: 10

YEAR: 2007

Dendritic cells in asthma and COPD: opportunities for drug development. Information

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LANGUAGE: eng

NlmUniqueID: 8900118

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Grant and Affiliation Information for Dendritic cells in asthma and COPD: opportunities for drug development.

AFFILIATION: Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

Country: England

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MEDLINETA: Curr Opin Immunol

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