Dendritic cell dysfunction in cancer: a mechanism for immunosuppression.

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Research Abstract Details 

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Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Abstract Text:

Alberto Pinzon-Charry,Tammy Maxwell,J Alejandro ,Alberto Pinzon-Charry,Tammy Maxwell,J Alejandro ,

Several reports have demonstrated that tumours are not intrinsically resistant to the immune response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A number of factors have been implicated in causing the failure, including aberrant antigen processing by tumour cells, anergy or deletion of T cells, and recruitment of inhibitory/regulatory cell types. It has been suggested that dysfunction of dendritic cells (DC) induced by the tumour is one of the critical mechanisms to escape immune surveillance. As a minor subset of leucocytes, DC are the key APC for initiating immune responses. DC are poised at the boundaries of the periphery and the inner tissues, sampling antigens of diverse origin. Following their encounter with antigen or danger signals, DC migrate to lymph nodes, where they activate effector cells essential for tumour clearance. Although the DC system is highly heterogeneous, the differentiation and function of DC populations is largely regulated by exogenous factors. Malignancies appear to exploit this by producing a plethora of immunosuppressive factors capable of affecting DC, thus exerting systemic effects on immune function. This review examines recent findings on the effects of tumour-derived factors inducing DC dysfunction and in particular examines the findings on alteration of DC differentiation, maturation and longevity as a potent mechanism for immune suppression in cancer.

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Publishing Authors By Initials

A Pinzon-Charry,T Maxwell,JA ,A Pinzon-Charry,T Maxwell,JA ,

For similar neoplasms research abstracts see: neoplasms research

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Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Journal Published:

PUBLICATION TYPE: Review

Journal: Immunology and cell biology

VOLUME: 83

Page Numbers: 451-61

Journal Abbreviation: Immunol. Cell Biol.

ISSN: 0818-9641

DAY: 3

MONTH: Oct

YEAR: 2005

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Information

Number of References: 117

LANGUAGE: eng

NlmUniqueID: 8706300

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: pathology

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Grant and Affiliation Information for Dendritic cell dysfunction in cancer: a mechanism for immunosuppression.

AFFILIATION: Dendritic Cell and Cancer Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.

Country: Australia

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MEDLINETA: Immunol Cell Biol

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