Dendrimeric pyridoxamine enzyme mimics.

Dendrimeric pyridoxamine enzyme mimics. Research Abstract Details 

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Dendrimeric pyridoxamine enzyme mimics. Abstract Text:

Lei Liu,Ronald Breslow,

PAMAM dendrimers from generations 1-6 were synthesized with pyridoxamine in their core. They transaminated pyruvic and phenylpyruvic acids in water to alanine and phenylalanine, respectively, with Michaelis-Menten kinetics and high effectiveness compared with simple pyridoxamine. The largest dendrimers-similar in size to some globular proteins-were comparable in effectiveness to a previous polyethylenimine (PEI)-pyridoxamine catalyst, and to a protein-pyridoxamine catalyst, but not as effective as a previous PEI-pyridoxamine carrying lauryl hydrophobic groups. The new catalysts showed both general acid/base catalysis by their amino groups and hydrophobic binding of the phenylpyruvate substrate.

Dendrimeric pyridoxamine enzyme mimics. Publishing Authors By Initials

L Liu,R Breslow,

For similar enzymes and coenzymes: enzymes: transferases: nitrogenous group transferases: transaminases research abstracts see: enzymes and coenzymes: enzymes: transferases: nitrogenous group transferases: transaminases research

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Dendrimeric pyridoxamine enzyme mimics. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 12110-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 8

MONTH: Oct

YEAR: 2003

Dendrimeric pyridoxamine enzyme mimics. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Dendrimeric pyridoxamine enzyme mimics. Keywords Mesh Terms:

KEYWORDS: Transaminases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dendrimeric pyridoxamine enzyme mimics. Information

Substance Name: Transaminases

Registry Number: EC 2.6.1.-

Grant and Affiliation Information for Dendrimeric pyridoxamine enzyme mimics.

AFFILIATION: Department of Chemistry, Columbia University, New York, New York 10027, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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