Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk.

Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk. Research Abstract Details 

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Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk. Abstract Text:

Sri Suravarapu,Eric J Bergstralh,Sara A Farmer,David S Knopman,Steven J Jacobsen,Rosebud O Roberts,

This study examines associations of serum total and bioavailable testosterone (T) with dementia in a community-based cohort of men. Study subjects (n=128; ages 65 y and older at baseline) were recruited in 1990 and followed through 2006. Dementia was assessed from the subject medical records on the basis of the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Serum from a blood draw performed in 1994 was assayed for total and bioavailable T. Twenty-one men developed dementia over 1186 person-years of follow-up. The cumulative incidence of dementia was 14.7% in men with total T <410 ng/mL (median) and 8.0% in men with higher levels [>/=410 ng/mL; age-adjusted hazard ratio (HR)=2.09; 95% confidence interval (CI)=0.76, 5.75]. Similarly, the cumulative incidence of dementia was 18.8% in men with bioavailable T <12 ng/mL (median) and 2.2% in men with bioavailable T >/=12 ng/mL; age-adjusted HR=1.22 (95% CI=0.38, 3.87). These findings do not demonstrate a significant association between T levels and dementia. However, they suggest a need for further investigation of these potential associations.

Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk. Publishing Authors By Initials

S Suravarapu,EJ Bergstralh,SA Farmer,DS Knopman,SJ Jacobsen,RO Roberts,

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Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Alzheimer disease and associated disorders

VOLUME: 20

Page Numbers: 138-40

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ISSN: 0893-0341

DAY: 3

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk.

AFFILIATION: Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.

Country: United States

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MEDLINETA: Alzheimer Dis Assoc Disord

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