Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats.

Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Research Abstract Details 

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Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Abstract Text:

Nobuaki Egashira,Noriko Ishigami,Kenichi Mishima,Katsunori Iwasaki,Ryozo Oishi,Michihiro Fujiwara,

Cannabis is the most widely used illicit substance. Delta(9)-Tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to induce cognitive impairment that closely resembles the impairment observed in schizophrenic patients. THC has also been known to impair spatial memory in rats tested in the eight-arm radial maze. We previously reported that microinjection of THC (20 mug/side) into the rat dorsal hippocampus impaired spatial memory and that i.p. injection of THC (6 mg/kg) decreased the extracellular levels of acetylcholine (ACh) in the dorsal hippocampus. In the present study, we compared the effects of olanzapine, an atypical antipsychotic, with those of haloperidol, a typical neuroleptic, on the impairments of spatial memory and decreased ACh levels induced by THC (6 mg/kg, i.p.) in rats. We found that olanzapine (0.1 mg/kg, i.p.) reversed the THC-induced memory deficits and decrease in extracellular ACh levels, whereas haloperidol (0.03-0.3 mg, i.p.) had no effect. These results suggest that olanzapine may improve the THC-induced impairment of spatial memory, partly by enhancing ACh release in the dorsal hippocampus. Therefore, olanzapine could attenuate the acute short-term and working memory deficits induced by cannabis.

Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Publishing Authors By Initials

N Egashira,N Ishigami,K Mishima,K Iwasaki,R Oishi,M Fujiwara,

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Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Progress in neuro-psychopharmacology & biological

VOLUME: 32

Page Numbers: 499-506

Journal Abbreviation: Prog. Neuropsychopharmacol. Bi

ISSN: 0278-5846

DAY: 10

MONTH: 10

YEAR: 2007

Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Delta(9)-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats.

AFFILIATION: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.

Country: England

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MEDLINETA: Prog Neuropsychopharmacol Biol

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