delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY.

delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY. Research Abstract Details 

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delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY. Abstract Text:

Min Zhao,Hong-Xin Wang,Jing Yang,Yu-Hong Su,Rong-Jian Su,Tak Ming Wong,Min Zhao,Hong-Xin Wang,Jing Yang,Yu-Hong Su,Rong-Jian Su,Tak Ming Wong,Min Zhao,Hong-Xin Wang,Jing Yang,Yu-Hong Su,Rong-Jian Su,Tak Ming Wong,

1. The aims of the present study were to determine whether delta-opioid receptor stimulation enhanced proliferation of and to investigate the role of the extracellular signal-regulated kinase (ERK) pathway in ventricular myocytes from neonatal rats. 2. At concentratins ranging from 10 nmol/L to 10 micromol/L, [d-Ala(2),d-Leu(5)]enkephalin (DADLE) concentration-dependently promoted myocardial growth and DNA synthesis and altered the cytoskeleton. 3. At 1 micromol/L, DADLE also increased the expression and phosphorylation of ERK. 4. These effects of 1 micromol/L DADLE were abolished by 10 micromol/L naltrindole, a selective delta-opioid receptor antagonist, 10 nmol/L U0126, a selective ERK antagonist, 1 micromol/L staurosporine, an inhibitor of protein kinase (PK) C, and 100 micromol/L Rp-adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate (Rp-cAMPS), an inhibitor of PKA. 5. In conclusion, delta-opioid receptor stimulation enhances the proliferation and development of the ventricular myocytes of neonatal rats. The ERK pathway and related signalling mechanisms, namely PKC and PKA, are involved.

delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY. Publishing Authors By Initials

M Zhao,HX Wang,J Yang,YH Su,RJ Su,TM Wong,M Zhao,HX Wang,J Yang,YH Su,RJ Su,TM Wong,M Zhao,HX Wang,J Yang,YH Su,RJ Su,TM Wong,

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delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental pharmacology & physiolog

VOLUME: 35

Page Numbers: 97-102

Journal Abbreviation: Clin. Exp. Pharmacol. Physiol.

ISSN: 0305-1870

DAY: 30

MONTH: Jan

YEAR: 2008

delta-OPIOID RECEPTOR STIMULATION ENHANCES THE GROWTH OF NEONATAL RAT VENTRICULAR MYOCYTES VIA THE EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAY. Information

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LANGUAGE: eng

NlmUniqueID: 425076

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AFFILIATION: Key Laboratory of Molecular Biology and Drug Research, Liaoning Medical College, Liaoning, China.

Country: Australia

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MEDLINETA: Clin Exp Pharmacol Physiol

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