Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers.

Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Research Abstract Details 

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Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Abstract Text:

Benjamin Thierry,Piotr Kujawa,Cathy Tkaczyk, Winnik,Luc Bilodeau,Maryam Tabrizian,

We report the design of a platform for the delivery of hydrophobic drugs via a macromolecular prodrug approach combined with LbL-assembled polyelectrolyte multilayers. A hyaluronan ester prodrug of the chemotherapeutic drug paclitaxel has been synthesized. Conjugation of the drug to hyaluronan through a labile succinate ester did not inhibit its activity. Using quartz crystal microbalance, atomic force microscopy, and UV spectroscopy, we have shown that the presence of the hydrophobic paclitaxel moieties does not prohibit the layer-by-layer construction of the multilayers. Release of the drug from the paclitaxel-loaded multilayers upon hydrolysis of the ester linkage resulted in a drastic cell death. Application of this delivery platform to substrates such as colloids, biomedical implants, or vascular tissues may lead to new therapeutic strategies.

Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Publishing Authors By Initials

B Thierry,P Kujawa,C Tkaczyk,FM Winnik,L Bilodeau,M Tabrizian,

For similar organic chemicals: carboxylic acids: acids, acyclic: dicarboxylic acids: succinic acids: succinic acid: succinates research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: dicarboxylic acids: succinic acids: succinic acid: succinates research

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Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 1626-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 16

MONTH: Feb

YEAR: 2005

Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Keywords Mesh Terms:

KEYWORDS: Succinates

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers. Information

Substance Name: Chitosan

Registry Number: 9012-76-4

Grant and Affiliation Information for Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers.

AFFILIATION: Department of Biomedical Engineering, McGill University, H3A 2B Montreal, Canada.

Country: United States

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MEDLINETA: J Am Chem Soc

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