Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency.

Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency. Research Abstract Details 

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Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency. Abstract Text:

Ania L Gheyara,Ainara Vallejo-Illarramendi,Keling Zang,Lin Mei,Rene St-Arnaud,Shoukat Dedhar,Louis F Reichardt,Ania L Gheyara,Ainara Vallejo-Illarramendi,Keling Zang,Lin Mei,Rene St-Arnaud,Shoukat Dedhar,Louis F Reichardt,Ania L Gheyara,Ainara Vallejo-Illarramendi,Keling Zang,Lin Mei,Rene St-Arnaud,Shoukat Dedhar,Louis F Reichardt,

Integrin-linked kinase (Ilk) is a serine/threonine kinase and an adaptor protein that links integrins to the actin cytoskeleton and to a number of signaling pathways involved in integrin action. We hypothesized that Ilk may act as an important effector of integrins in skeletal muscle, where these receptors provide a critical link between the sarcolemma and the extracellular matrix. Using the cre/lox system, we deleted Ilk from skeletal muscles of mice. The resulting mutants developed a progressive muscular dystrophy with multiple degenerating and regenerating muscle fibers, increased central nuclei, and endomysial fibrosis. These defects were widespread but were most severe near myofascial junctions where Ilk mutants showed displacement of focal adhesion-related proteins, including vinculin, paxillin, focal adhesion kinase, dystrophin, and the alpha7beta1D-integrin subunits. Distal ends of mutant muscle fibers appeared irregular, and there was restructuring of the actin cytoskeleton. These findings resemble those seen in humans and mice lacking the alpha7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha7beta1-integrin in the pathogenesis of these deficiencies.

Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency. Publishing Authors By Initials

AL Gheyara,A Vallejo-Illarramendi,K Zang,L Mei,R St-Arnaud,S Dedhar,LF Reichardt,AL Gheyara,A Vallejo-Illarramendi,K Zang,L Mei,R St-Arnaud,S Dedhar,LF Reichardt,AL Gheyara,A Vallejo-Illarramendi,K Zang,L Mei,R St-Arnaud,S Dedhar,LF Reichardt,

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Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of pathology

VOLUME: 171

Page Numbers: 1966-77

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 30

MONTH: 11

YEAR: 2007

Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to {alpha}7 1-Integrin Deficiency. Information

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LANGUAGE: eng

NlmUniqueID: 370502

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AFFILIATION: Department of Physiology, University of California, San Francisco, San Francisco, California 94143. louis.Reichardt@ucsf.edu.

Country: United States

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MEDLINETA: Am J Pathol

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