Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections.

Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. Research Abstract Details 

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Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. Abstract Text:

Candace Y Hsieh,Cindy T Hong,Karina S Cramer,Candace Y Hsieh,Cindy T Hong,Karina S Cramer,

Axonal selection of ipsilateral and/or contralateral targets is essential for integrating bilateral sensory information and for coordinated movement. The molecular processes that determine ipsilateral and contralateral target choice are not fully understood. We examined this target selection in the developing auditory brainstem. Ventral cochlear nucleus (VCN) axons normally project to the medial nucleus of the trapezoid body (MNTB) only on the contralateral side. However, after unilateral removal of cochlear input in neonates, we found that axons from the unoperated VCN sprout and project to MNTB bilaterally. We found that EphA4 is expressed in the mouse auditory brainstem during development and during a sensitive period for ipsilateral sprouting, so we hypothesized that deletion of the Eph receptor EphA4 would impair target selection in these auditory pathways. Lipophilic dyes were used to evaluate quantitatively the brainstem projections in wild-type and EphA4-null mice. VCN-MNTB projections in EphA4-null mice were strictly contralateral, as in wild-type mice. However, after deafferentation, EphA4-null mice had a significant, threefold increase in the proportion of axons from the intact VCN that sprouted into ipsilateral MNTB compared with wild-type mice. Heterozygous mice had a twofold increase in these projections. These results demonstrate that EphA4 influences auditory brainstem circuitry selectively in response to deafferentation. Although this axon guidance molecule is not by itself necessary for appropriate target choice during normal development, it is a strong determinant of ipsilateral vs. contralateral target choice during deafferentation-induced plasticity.

Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. Publishing Authors By Initials

CY Hsieh,CT Hong,KS Cramer,CY Hsieh,CT Hong,KS Cramer,

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Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of comparative neurology

VOLUME: 504

Page Numbers: 508-18

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 10

MONTH: Oct

YEAR: 2007

Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections.

AFFILIATION: Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697-4550, USA.

Country: United States

AGENCY: United States NIDCD

GRANT: DC007538

ACRONYM: DC

MEDLINETA: J Comp Neurol

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