Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.

Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Research Abstract Details 

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Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Abstract Text:

Wennuan Liu,Bao-Li Chang,Scott Cramer,Patrick P Koty,Tao Li,Jishan Sun,Aubrey R Turner,Chris Von Kap-Herr,Peggy Bobby,Jianyu Rao,S Lilly Zheng,William B Isaacs,Jianfeng Xu,

PURPOSE: Chromosome 6q14-21 is commonly deleted in prostate cancers, occurring in approximately 22% of all tumors and approximately 40% of metastatic tumors. However, candidate prostate tumor suppressor genes in this region have not been identified, in part due to the large and broad nature of the deleted region implicated in previous studies. EXPERIMENTAL DESIGN: We first used high-resolution Affymetrix single nucleotide polymorphism arrays to examine DNA from malignant and matched nonmalignant cells from 55 prostate cancer patients. We identified a small consensus region on 6q14-21 and evaluated the deletion status within the region among additional 40 tumors and normal pairs using quantitative PCR and fluorescence in situ hybridization. We finally tested the association between the deletion and Gleason score using the Fisher's exact test. RESULTS: Tumors with small, interstitial deletions at 6q14-21 defined an 817-kb consensus region that is affected in 20 of 21 tumors. The MAP3K7 gene is one of five genes located in this region. In total, MAP3K7 was deleted in 32% of 95 tumors. Importantly, deletion of MAP3K7 was highly associated with higher-grade disease, occurring in 61% of tumors with Gleason score >or=8 compared with only 22% of tumors with Gleason score

Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Publishing Authors By Initials

W Liu,BL Chang,S Cramer,PP Koty,T Li,J Sun,AR Turner,C Von Kap-Herr,P Bobby,J Rao,SL Zheng,WB Isaacs,J Xu,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research

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Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical cancer research : an official journal of

VOLUME: 13

Page Numbers: 5028-33

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Sep

YEAR: 2007

Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Keywords Mesh Terms:

KEYWORDS: Prostatic Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Information

Substance Name: MAP Kinase Kinase Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.

AFFILIATION: Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA95052

ACRONYM: CA

MEDLINETA: Clin Cancer Res

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