Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods.

Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Research Abstract Details 

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Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Abstract Text:

Molly Duman-Scheel,Stephanie M Clark,Eric T Grunow,Andrew O Hasley,Brandon L Hill,Wendy L Simanton,

Although many similarities in arthropod central nervous systems (CNS) development exist, differences in midline cell formation and ventral nerve cord axonogenesis have been noted in arthropods. It is possible that changes in the expression of axon guidance molecules such as Netrin, which functions during commissural axon guidance in Drosophila and many other organisms, may parallel these differences. In this investigation, we analyze this hypothesis by examining Netrin accumulation during development of the brine shrimp Artemia franciscana, a branchiopod crustacean. An Artemia franciscana netrin (afrnet) orthologue was cloned. An antibody to the afrNet protein was generated and used to examine the pattern of afrNet accumulation during Artemia development. Despite differences between Drosophila and Artemia nerve cord development, examination of afrNet accumulation suggests that this protein functions to regulate commissure formation during Artemia CNS development. However, detection of afrNet at the midline and on commissural axons occurs at a relatively later time point in Artemia as compared with Drosophila. Detection of afrNet in a subset of midline cells that closely resemble Netrin-expressing cells at the Drosophila midline provides evidence for homology of midline cells in arthropods. Expression of Netrins in many other tissues is comparable, suggesting that Netrin proteins may play many conserved roles during arthropod development.

Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Publishing Authors By Initials

M Duman-Scheel,SM Clark,ET Grunow,AO Hasley,BL Hill,WL Simanton,

For similar peptides: intercellular signaling peptides and proteins: nerve growth factors research abstracts see: peptides: intercellular signaling peptides and proteins: nerve growth factors research

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Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Evolution & development

VOLUME: 9

Page Numbers: 131-40

Journal Abbreviation: Evol. Dev.

ISSN: 1520-541X

DAY: 3

MONTH: 12

YEAR: 2007

Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Information

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LANGUAGE: eng

NlmUniqueID: 100883432

Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Keywords Mesh Terms:

KEYWORDS: Nerve Growth Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods. Information

Substance Name: Nerve Growth Factors

Registry Number: 0

Grant and Affiliation Information for Delayed onset of midline netrin expression in Artemia franciscana coincides with commissural axon growth and provides evidence for homology of midline cells in distantly related arthropods.

AFFILIATION: Deptartment of Biology, Albion College, 611 E. Porter, Albion, MI 49224, USA. mscheel@albion.edu

Country: United States

AGENCY: United States NINDS

GRANT: R15 NS048904-0

ACRONYM: NS

MEDLINETA: Evol Dev

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