Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy.

Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Research Abstract Details 

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Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Abstract Text:

J Sancho,J Egido,F Rivera,L Hernando,

The presence of multimeric (polymeric and monomeric) IgA immune complexes (IC), detected by Raji cell assay and by the inhibition binding assay, as well as the specific polymeric IgA-IC were examined before and after the ingestion of 100 g protein. A rise in multimeric IgA-IC occurred in three out of seven controls with a peak at two to four hours after the meal, being cleared thereafter. The amount of multimeric IC present at fasting in four of six patients diminished at two to four hours after food challenge reaching a new peak around six hours. In both controls and patients, IC containing antibodies against diet antigens (e.g. ovalbumin) paralleled those of multimeric IgA-IC. In controls the specific polymeric IgA-IC presented a maximal peak with distribution similar to multimeric IgA-IC, but with a faster disappearance from the circulation. By contrast, polymeric IgA-IC remained elevated 24 hours after food ingestion in most patients. These results suggest that a defect in the hepatic clearance of circulating polymeric IgA-IC exists in patients with IgA nephropathy.

Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Publishing Authors By Initials

J Sancho,J Egido,F Rivera,L Hernando,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the European Dialysis and Transplan

VOLUME: 20

Page Numbers: 617-22

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ISSN: 0071-2736

DAY: 21

MONTH: 02

YEAR: 1983

Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Information

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LANGUAGE: eng

NlmUniqueID: 355210

Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: immunology

Chemical & Substance for Abstract: Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Delayed clearance of specific polymeric IgA immune complexes in patients with IgA nephropathy.

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Country: ENGLAND

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MEDLINETA: Proc Eur Dial Transplant Assoc

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