Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair.

Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Research Abstract Details 

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Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Abstract Text:

T A Holland,E W H Bodde,V M J I Cuijpers,L S Baggett,Y Tabata,A G Mikos,J A Jansen,

OBJECTIVE: As our population ages, treatment for joint pain associated with articular cartilage damage is becoming a prevalent challenge. Accordingly, this work investigates local delivery of two regulatory proteins - transforming growth factor-beta1 (TGF-beta1) and insulin-like growth factor-1 (IGF-1) - to cartilage defects from degradable scaffolds as a potential strategy for improving cartilage repair. METHOD: The effects of TGF-beta1 and/or IGF-1 delivery on osteochondral repair in adult rabbits were examined through histomorphometric analysis of 11 markers of osteochondral repair. RESULTS: Complete scaffold degradation occurred allowing for assessment of the healing response at 12 weeks post-surgery. When compared to untreated defects, higher scores were observed with IGF-1-treated defects for the six markers of neo-surface repair: neo-surface morphology, cartilage thickness, surface regularity, chondrocyte clustering, and the chondrocyte/glycosaminoglycan content of the neo-surface and the cartilage surrounding the defect. Surprisingly, the benefits of IGF-1 delivery were not maintained when this growth factor (GF) was co-delivered with TGF-beta1, despite numerous in vitro reports of the combinatory actions of these GFs. CONCLUSIONS: While localized delivery of IGF-1 may be a promising repair strategy, further in vivo assessment is necessary, since fibrous tissue was commonly observed in the neo-surface of all treatment groups. More importantly, this study highlights the need to rigorously examine GF interactions in the wound healing environment and demonstrates that in vitro observations do not directly translate to the in vivo setting.

Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Publishing Authors By Initials

TA Holland,EW Bodde,VM Cuijpers,LS Baggett,Y Tabata,AG Mikos,JA Jansen,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

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Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Osteoarthritis and cartilage / OARS, Osteoarthriti

VOLUME: 15

Page Numbers: 187-97

Journal Abbreviation: Osteoarthr. Cartil.

ISSN: 1063-4584

DAY: 11

MONTH: 09

YEAR: 2006

Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9305697

Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Information

Substance Name: Insulin-Like Growth Factor I

Registry Number: 67763-96-6

Grant and Affiliation Information for Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair.

AFFILIATION: Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251-1892, USA.

Country: England

AGENCY: United States NIAMS

GRANT: R01 AR48756

ACRONYM: AR

MEDLINETA: Osteoarthritis Cartilage

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