Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal.

Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Research Abstract Details 

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Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Abstract Text:

D Ndiaye,J P Daily,O Sarr,O Ndir,O Gaye,S Mboup,C Roper,D F Wirth,

We previously reported a high baseline prevalence of mutations in the dhfr and dhps genes of Plasmodium falciparum throughout Senegal. The highest prevalence of the triple dhfr pyrimethamine associated mutations were found in isolates obtained in the western part of the country near the capital city of Dakar. In this study, we sought out to determine the relatedness of dhfr wild type and mutated strains by analyzing three microsatellite regions upstream of the dhfr locus. Twenty-six of the 31 wild type strains had a unique microsatellite pattern. In contrast, of the 17 isolates containing the triple mutation in dhfr, 11 had an identical microsatellite pattern. Diverse geographical isolates in Senegal containing the triple dhfr mutation have arisen from a limited number of ancestral strains. In addition, we demonstrate that these isolates have shared ancestry with the previously reported triple mutation haplotype found in Tanzania, South Africa, and southeast Asia. This common ancestry may have implications for the malaria control strategy for reducing the spread of sulfadoxine-pyrimethamine resistance in Senegal and elsewhere in Africa.

Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Publishing Authors By Initials

D Ndiaye,JP Daily,O Sarr,O Ndir,O Gaye,S Mboup,C Roper,DF Wirth,

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Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Acta tropica

VOLUME: 99

Page Numbers: 106-11

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ISSN: 0001-706X

DAY: 14

MONTH: 08

YEAR: 2006

Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal.

AFFILIATION: Department of Parasitology and Mycology, Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.

Country: Netherlands

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MEDLINETA: Acta Trop

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