Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.

Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Research Abstract Details 

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Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Abstract Text:

Yang Kang,Xiang Chen,Jeffrey W Lary,James L Cole,Kylie J Walters,

Ubiquitin receptors connect substrate ubiquitylation to proteasomal degradation. HHR23a binds proteasome subunit 5a (S5a) through a surface that also binds ubiquitin. We report that UIM2 of S5a binds preferentially to hHR23a over polyubiquitin, and we provide a model for the ternary complex that we expect represents one of the mechanisms used by the proteasome to capture ubiquitylated substrates. Furthermore, we demonstrate that hHR23a is surprisingly adept at sequestering the ubiquitin moieties of a polyubiquitin chain, and provide evidence that it and the ubiquitylated substrate are committed to each other after binding.

Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Publishing Authors By Initials

Y Kang,X Chen,JW Lary,JL Cole,KJ Walters,

For similar enzymes and coenzymes: enzymes: ligases: ubiquitin-protein ligase complexes: ubiquitin-activating enzymes research abstracts see: enzymes and coenzymes: enzymes: ligases: ubiquitin-protein ligase complexes: ubiquitin-activating enzymes research

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Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of molecular biology

VOLUME: 369

Page Numbers: 168-76

Journal Abbreviation:

ISSN: 0022-2836

DAY: 12

MONTH: 03

YEAR: 2007

Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985088

Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Keywords Mesh Terms:

KEYWORDS: Ubiquitin-Activating Enzymes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. Information

Substance Name: Ubiquitin-Activating Enzymes

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.

AFFILIATION: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Country: England

AGENCY: United States NCI

GRANT: CA097004

ACRONYM: CA

MEDLINETA: J Mol Biol

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