Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Abstract Text:

Brendan B L Pillemer,Hui Xu,Timothy B Oriss,Zengbiao Qi,Anuradha Ray,

Naturally occurring CD4+CD25+FoxP3+ regulatory T cells (Treg) suppress T helper (Th) cell-mediated immune responses. The cytokines IL-2 and IL-6 are known to influence Treg function. However, their relative effects on Th cells versus Treg are not well understood. Stimulation with IL-2, and to a lesser extent, IL-6, enhanced Treg proliferation, FoxP3 and CTLA4 maintenance, and suppressive function. In contrast, when IL-2 or IL-6 were added to Treg/Th cell cocultures, suppression was inhibited. The molecule SOCS3 negatively regulates responses to IL-2 and IL-6. Interestingly, unlike Th cells, Treg were found to be deficient in SOCS3 protein expression. The significance of this finding lies in the need for Treg to rapidly respond to these cytokines to prevent unwarranted immune responses to self-antigens. Overexpression of SOCS3 in Treg decreased their proliferation, FoxP3 and CTLA-4 expression and suppressive function. Thus, up-regulation of SOCS3 expression may be a useful therapeutic approach in diseases where inhibition of Treg is desirable.

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Publishing Authors By Initials

BB Pillemer,H Xu,TB Oriss,Z Qi,A Ray,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research

PUBMED ID PMID:

MEDLINE DATE:

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 2082-9

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Aug

YEAR: 2007

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Regulatory

MESH TERMS: metabolism

Chemical & Substance for Abstract: Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Information

Substance Name: Suppressor of Cytokine Signaling Protein

Registry Number: 0

Grant and Affiliation Information for Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.

AFFILIATION: Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Country: Germany

AGENCY: United States NCI

GRANT: T32 CA82084

ACRONYM: CA

MEDLINETA: Eur J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function Related Publications

• 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells.
• A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice.
• Adenovirus-mediated gene transfer to renal glomeruli in rodents.
• Aldosterone impairs baroreflex sensitivity in healthy adults.
• Alkaloids of Fumaria indica: Further Studies on Narceimine and Narlumidine.
• Chemical Constituents of the Leaves of Flueggea microcarpa.
• Currently evaluated calpain and caspase inhibitors for neuroprotection in experimental brain ischemia.
• Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.
• Effect of acute hyperlipidemia on autonomic and cardiovascular control in humans.
• Effect of elevating serum lipids on luteinizing hormone response to gonadotrophin releasing hormone challenge in energy-deficient anestrous heifers.
• Effects of Exercise TVaining on Brachial and Femoral Myogenic Responses in Young Subjects: 1685: Board #175 May 30 2:00 PM - 3:30 PM.
• Estrous response of early postpartum beef heifers to progesterone and estradiol-17beta during restricted dietary energy.
• Fallen between the Cracks: Conservation Linking Land and Sea.
• Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells.
• Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.
• Increasing use of antidepressants in pregnancy.
• Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human malignant glioblastoma T98G and U87MG cells.
• Influence of static magnetic fields on pain perception and sympathetic nerve activity in humans.
• Major Alkaloid and Flavonoid of Premna integrifolia.
• Percent positive biopsy cores as a prognostic factor for prostate cancer treated with external beam radiation.
• Phenolic Constituents of Rhus semialata Leaves.
• Physalindicanols, New Biogenetic Precursors of C28-Steroidal Lactones from Physalis minima var. indica.
• Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution.
• RBx 7,796: A novel inhibitor of 5-lipoxygenase.
• Regulation and characterization of rot transcription in Staphylococcus aureus.
• Review of kinetics of chemical and photocatalytical oxidation of Arsenic(III) as influenced by pH.
• Small interfering RNA targeted to hepatitis C virus 5' nontranslated region exerts potent antiviral effect.
• Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes.
• Transfusion support to Dengue patients in a hospital based blood transfusion service in north India.
• Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.