Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis.

Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Research Abstract Details 

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Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Abstract Text:

Jinliang Xing,Margaret R Spitz,Charles Lu,Hua Zhao,Hushan Yang,Wei Wang,David J Stewart,Xifeng Wu,

Loss or attenuation of cell cycle checkpoint function can compromise the fidelity of DNA due to insufficient time to repair DNA damage. We evaluated cell cycle checkpoints in 747 patients with lung cancer and 745 controls by measuring the proportions of cultured peripheral blood lymphocytes in G2-M and S phases. As an indicator of G2-M phase or S phase cell cycle checkpoint function, the gamma-radiation-induced cell accumulation index at G2-M or S phase was defined as (percentage of cells in G2-M or S with ionizing radiation exposure - percentage of cells in G2-M or S without ionizing radiation exposure) / (percentage of cells in G2-M or S without ionizing radiation exposure). We found that the median cell accumulation index was significantly lower in patients than that in controls at both the G2-M phase (0.774 versus 0.882, P = 0.002) and the S phase (0.226 versus 0.243, P = 0.001). When the median value for the cell accumulation index at the G2-M or S phase in the controls was used as the cutoff point, the reduced indices at G2-M and S phases were associated with 1.28-fold (95% confidence interval, 1.04-1.58) and 1.30-fold (95% confidence interval, 1.06-1.61) increased lung cancer risks, respectively. Analyses stratified by histology showed some heterogeneity. Additionally, cell accumulation indices at both G2-M and S phases were not associated with clinical stages. We conclude that attenuated functions of G2-M and S cell cycle checkpoints might be susceptibility markers for lung cancer.

Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Publishing Authors By Initials

J Xing,MR Spitz,C Lu,H Zhao,H Yang,W Wang,DJ Stewart,X Wu,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research

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Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1517-22

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Jul

YEAR: 2007

Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Information

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LANGUAGE: eng

NlmUniqueID: 9200608

Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis. Keywords Mesh Terms:

KEYWORDS: S Phase

MESH TERMS: radiation effects

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Grant and Affiliation Information for Deficient G2-M and S checkpoints are associated with increased lung cancer risk: a case-control analysis.

AFFILIATION: Department of Epidemiology, Unit 1340, The University of Texas M. D. Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA70907

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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