Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation.

Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Research Abstract Details 

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Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Abstract Text:

S Henriquez,A Tapia,M Quezada,M Vargas,H Cardenas,M Rios,A M Salvatierra,H Croxatto,P Orihuela,F Zegers-Hochschild,D J Munroe,L Velasquez,

Successful implantation depends both on the quality of the embryo and on the endometrial receptivity. The latter depends on progesterone-induced changes in gene expression, a process that has been characterized by microarray analysis. One of the genes whose transcription appears to be enhanced during the receptive period is monoamine oxidase A (MAO-A). Our first objective was to confirm the increased expression of MAO-A in the endometrium during the receptive phase of spontaneous normal cycles using real time PCR and immunofluorescence. The second objective was to examine the endometrial expression of MAO-A during the receptive phase induced by exogenous estradiol (E(2)) and progesterone in patients whose endometrium was shown to have been either receptive or non-receptive to embryo implantation in repeated cycles of oocyte donation. Results showed that MAO-A transcript levels increased between the pre-receptive (LH+3) and receptive phase (LH+7) in all spontaneous cycles examined, with a median increase of 25-fold. Immunofluorescent labelling demonstrated MAO-A localization to the glandular and luminal epithelium with an increasing positive score between LH+3 and LH+7. Conversely, prior failure of embryo implantation was associated with a 29-fold decrease in MAO-A mRNA levels and a substantial reduction in MAO-A protein immunofluorescent label score. These results show a strong association between endometrial receptivity and MAO-A expression in the endometrial epithelium, suggesting an important role for this enzyme in normal implantation.

Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Publishing Authors By Initials

S Henriquez,A Tapia,M Quezada,M Vargas,H Cardenas,M Rios,AM Salvatierra,H Croxatto,P Orihuela,F Zegers-Hochschild,DJ Munroe,L Velasquez,

For similar cells: connective tissue cells: stromal cells research abstracts see: cells: connective tissue cells: stromal cells research

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Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular human reproduction

VOLUME: 12

Page Numbers: 749-54

Journal Abbreviation: Mol. Hum. Reprod.

ISSN: 1360-9947

DAY: 4

MONTH: 10

YEAR: 2006

Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9513710

Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Keywords Mesh Terms:

KEYWORDS: Stromal Cells

MESH TERMS: enzymology

Chemical & Substance for Abstract: Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation. Information

Substance Name: Monoamine Oxidase

Registry Number: EC 1.4.3.4

Grant and Affiliation Information for Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation.

AFFILIATION: Laboratorio de Inmunología de la Reproducción, Universidad de Santiago de Chile.

Country: England

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: Mol Hum Reprod

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