Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity.

Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Research Abstract Details 

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Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Abstract Text:

Jiyoung Hong,Sung Tae Kim,Susanne Tranguch,David F Smith,Sudhansu K Dey,

FKBP52 is a member of the FK506-binding family of immunophilins and serves as a co-chaperone for steroid hormone nuclear receptors to govern appropriate hormone action in target tissues. Male mice missing Fkbp52 are infertile, and this infertility has been ascribed to compromised sensitivity of the anterior prostate, external genitalia, and other accessory sex organs to androgen. Here, we show additional defects contributing to infertility. We found that epididymal Fkbp52(-/-) sperm are sparse often with aberrant morphology, and they have reduced fertilizing capacity. This phenotype, initially observed in null males on a C57BL/6/129 background, is also maintained on a CD1 background. Expression studies show that while FKBP52 and androgen receptor are co-expressed in similar cell types in the epididymis, FKBP52 is also present in epididymal sperm flagella. Collectively, our results suggest that reduced number and abnormal morphology contribute to compromised fertilizing capacity of Fkbp52(-/-) sperm. This study is clinically relevant because unraveling the role of immunophilin signaling in male fertility will help identify new targets for male contraceptives and/or alleviate male infertility.

Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Publishing Authors By Initials

J Hong,ST Kim,S Tranguch,DF Smith,SK Dey,

For similar enzymes and coenzymes: enzymes: isomerases: cis-trans-isomerases: peptidylprolyl isomerase: immunophilins: tacrolimus binding proteins research abstracts see: enzymes and coenzymes: enzymes: isomerases: cis-trans-isomerases: peptidylprolyl isomerase: immunophilins: tacrolimus binding proteins research

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Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Reproduction (Cambridge, England)

VOLUME: 133

Page Numbers: 395-403

Journal Abbreviation: Reproduction

ISSN: 1470-1626

DAY: 3

MONTH: Feb

YEAR: 2007

Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100966036

Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Keywords Mesh Terms:

KEYWORDS: Tacrolimus Binding Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Information

Substance Name: tacrolimus binding protein 4

Registry Number: EC 5.2.1.-

Grant and Affiliation Information for Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity.

AFFILIATION: Pediatrics, Cell and Developmental Biology, Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD 12304

ACRONYM: HD

MEDLINETA: Reproduction

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