Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity. Research Abstract Details 

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Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity. Abstract Text:

Cytosolic malic enzyme (ME-1) is a nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzyme that generates NADPH. The activity of this enzyme, the reversible oxidative decarboxylation of malate to yield pyruvate, links glycolytic pathway to citric acid cycle. The high level of ME-1 expression in liver, and its involvement in NADPH production, suggests reduced ME-1 activity might compromise hepatic production of reduced glutathione (GSH) by the NADPH-dependent enzyme glutathione reductase, and hence affect xenobiotic detoxification. The role of ME-1 in liver detoxification was evaluated in Mod1 deficient mice (mod1(-/-)) by evaluating their sensitivity to acetaminophen-induced liver injury. The results show that mod1(-/-) mice are not more sensitive to acetaminophen hepato-toxicity. Although GSH levels were initially depleted more in the mod1(-/-) liver than in wild-type controls, the GSH levels recovered quickly. In conclusion, our data indicate that ME-1 deficiency does not adversely affect GSH-dependent detoxification.

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity. Publishing Authors By Initials

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Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Basic & clinical pharmacology & toxicology

VOLUME: 103

Page Numbers: 36-42

Journal Abbreviation: Basic Clin. Pharmacol. Toxicol

ISSN: 1742-7843

DAY: 1

MONTH: 07

YEAR: 2008

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity. Information

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LANGUAGE: eng

NlmUniqueID: 101208422

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Grant and Affiliation Information for Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

AFFILIATION: Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, USA.

Country: Denmark

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MEDLINETA: Basic Clin Pharmacol Toxicol

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