Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension.

Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Research Abstract Details 

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Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Abstract Text:

Rogerio B Wichi,Vera Farah,Yanfang Chen,Maria Claudia Irigoyen,Mariana Morris,

The renin-angiotensin system has been implicated in the etiology of the cardiovascular complications of diabetes. Our studies extend these findings to show a specific role for angiotensin AT1a receptors in mediating diabetes-induced hypertension. Male angiotensin AT1a knockout (AT1aKO) and wild-type (AT1aWT) mice with arterial telemetric catheters were injected with streptozotocin (STZ; 150 mg/kg ip). The STZ dose was selected on the basis of a dose-response experiment in C57/BL mice. Blood glucose, water intake, body weight, blood pressure (BP), and heart rate (HR) were measured over a 2-wk period. Estimates of BP and HR variance (BPV and HRV) and their low- and high-frequency domains were also determined. STZ induced similar levels of hyperglycemia and polydypsia in the groups. Mean arterial pressure (MAP) was increased from 100 +/- 6 to 124 +/- 6 mmHg in diabetic AT1aWT. MAP was unchanged in AT1aKO (80 +/- 4 vs. 85 +/- 5 mmHg, basal vs. STZ). Treatment with an ACE inhibitor, captopril, produced a greater reduction in MAP (-18%) in diabetic AT1aWT than in AT1aKO (-3.4%). BPV was lower in AT1aKO (19 +/- 0.5 vs. 9 +/- 2 mmHg(2), AT1aWT vs. AT1aKO). Diabetes reduced BPV but only in AT1aWT (19 +/- 0.5 vs. 8 +/- 1 mmHg(2), basal vs. STZ). There were no changes in HR in either group. In AT1aKO, STZ increased HRV and its high-frequency domain with no changes seen in AT1aWT. Results document that ANG AT1a receptors are critical in diabetes-induced hypertension and in cardiac autonomic responses.

Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Publishing Authors By Initials

RB Wichi,V Farah,Y Chen,MC Irigoyen,M Morris,

For similar organic chemicals: nitroso compounds: nitrosourea compounds: streptozocin research abstracts see: organic chemicals: nitroso compounds: nitrosourea compounds: streptozocin research

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Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Regulatory, integr

VOLUME: 292

Page Numbers: R1184-9

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 22

MONTH: 11

YEAR: 2006

Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Keywords Mesh Terms:

KEYWORDS: Streptozocin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension. Information

Substance Name: Streptozocin

Registry Number: 18883-66-4

Grant and Affiliation Information for Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension.

AFFILIATION: Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL 69319

ACRONYM: HL

MEDLINETA: Am J Physiol Regul Integr Comp

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