Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.

Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Research Abstract Details 

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Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Abstract Text:

Neurotrophic support of developing neurons by neurotrophins is of critical importance in the development of fungiform papillae and taste buds. A number of neurological disorders show a decrease or increase in fungiform papillae or taste sensation. These can be grouped into disorders with reduced papillae (Machado-Joseph disease, Stüve-Wiedemann syndrome, familial dysautonomia, dystonia musculorum, and Behçet's disease) and those with taste defects only (Alzheimer's disease, Huntington's disease, hereditary sensory and autonomic neuropathy type IV, and diabetes mellitus). In addition, Parkinson's disease results in increased taste sensation. Here, we hypothesize that the main problem in these disorders is either not enough or too much neurotrophic support. Proneurotrophic drugs such as some antidepressants and aldose reductase inhibitors may prove useful in the treatment of these sensory and central nervous system disorders. Similarly, antineurotrophic drugs may also be useful in Parkinson's disease. Here we show that the protein involved in familial dysautonomia, IKAP, localizes to keratin filaments in HeLa cells, suggesting a role for the keratin cytoskeleton in neurotrophic support. NEUROSCIENTIST 14(3):240-250, 2008. DOI: 10.1177/1073858407312382.

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Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Neuroscientist : a review journal bringing neu

VOLUME: 14

Page Numbers: 240-50

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ISSN: 1073-8584

DAY: 12

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.

AFFILIATION: School of Biological Sciences, the University of Sydney, Australia. jgardiner@mail.usyd.edu.au.

Country: United States

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MEDLINETA: Neuroscientist

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