Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Abstract Text:

Ping Wei,Takaya Satoh,Hironori Edamatsu,Atsu Aiba,Tomiyoshi Setsu,Toshio Terashima,Sohei Kitazawa,Kazuki Nakao,Yoko Yoshikawa,Masako Tamada,Tohru Kataoka,Ping Wei,Takaya Satoh,Hironori Edamatsu,Atsu Aiba,Tomiyoshi Setsu,Toshio Terashima,Sohei Kitazawa,Kazuki Nakao,Yoko Yoshikawa,Masako Tamada,Tohru Kataoka,

A multitude of guanine nucleotide exchange factors (GEFs) regulate Rap1 small GTPases, however, their individual functions remain obscure. Here, we investigate the in vivo function of the Rap1 GEF RA-GEF-1. The expression of RA-GEF-1 in wild-type mice starts at embryonic day (E) 8.5, and continues thereafter. RA-GEF-1(-/-) mice appear normal until E7.5, but become grossly abnormal and dead by E9.5. This mid-gestation death appears to be closely associated with severe defects in yolk sac blood vessel formation. RA-GEF-1(-/-) yolk sacs form apparently normal blood islands by E8.5, but the blood islands fail to coalesce into a primary vascular plexus, indicating that vasculogenesis is impaired. Furthermore, RA-GEF-1(-/-) embryos proper show severe defects in the formation of major blood vessels. These results suggest that deficient Rap1 signaling may lead to defective vascular morphogenesis in the yolk sac and embryos proper.

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Publishing Authors By Initials

P Wei,T Satoh,H Edamatsu,A Aiba,T Setsu,T Terashima,S Kitazawa,K Nakao,Y Yoshikawa,M Tamada,T Kataoka,P Wei,T Satoh,H Edamatsu,A Aiba,T Setsu,T Terashima,S Kitazawa,K Nakao,Y Yoshikawa,M Tamada,T Kataoka,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 106-12

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 10

MONTH: 09

YEAR: 2007

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.

AFFILIATION: Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1 Related Publications

• A histochemical study on glycoconjugates in epithelial cells in the distal colonic mucosa of adult and developing mice.
• AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles.
• Adverse Effect of Cyclosporin A on Barrier Functions of Cerebral Microvascular Endothelial Cells After Hypoxia-reoxygenation Damage In Vitro.
• Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles.
• Carbocyclization Reaction of omega-Iodo- and 1,omega-Diiodo-1-alkynes without the Loss of Iodine Atoms through a Carbenoid-Chain Process.
• Complement activation plays a key role in antibody-induced infusion toxicity in monkeys and rats.
• Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
• Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen.
• Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.
• Differential Regulation of Ecdysteroidogenic P450 Gene Expression in the Silkworm, Bombyx mori.
• Effect of organic anions on the photoreaction of photoactive yellow protein.
• Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity.
• Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.
• MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.
• Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule.
• Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes.
• PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery.
• Phospholipase cepsilon Guanine nucleotide exchange factor activity and activation of rap1.
• Ras and Rap1 Activation of PLCvarepsilon Lipase Activity.
• Roles and Regulation of Transcription Factor MafA in Islet beta-cells.
• Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells.
• Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.
• Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice.
• Structure and function of type I copper in multicopper oxidases.
• Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing.
• Surgical repair for entire inferior vena cava occlusion in budd-Chiari syndrome.
• Unusual segmental stricture of the lower common bile duct mimicking bile duct cancer.
• [Pharmaceutical support at cardiovascular and cardiovascular surgery ward]
• [Type 1 allergy to formaldehyde in root canal sealant after dental treatment: two case reports and review of the literature]
• gamma-Tubulin-like molecules in the mouse duodenal epithelium.