Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma.

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Abstract Text:

Eijiro Asano,Kiyofumi Mochizuki,Akira Sawada,Ei-ichiro Nagasaka,Yuji Kondo,Tetsuya Yamamoto,Eijiro Asano,Kiyofumi Mochizuki,Akira Sawada,Ei-ichiro Nagasaka,Yuji Kondo,Tetsuya Yamamoto,Eijiro Asano,Kiyofumi Mochizuki,Akira Sawada,Ei-ichiro Nagasaka,Yuji Kondo,Tetsuya Yamamoto,

PURPOSE: To determine whether multifocal electroretinograms (mfERGs) can provide an index for identification of glaucomatous optic neuropathy in patients with normal-tension glaucoma (NTG). METHODS: mfERGs were recorded in 30 normal volunteers (30 eyes) and 20 patients (20 eyes) with normal-tension glaucoma (NTG). Visual field examinations were performed with a Humphrey field analyzer, and all NTG patients had unilateral hemifield defects. The mfERGs were elicited by a binary m-sequence of flashes from 37 hexagonal elements that subtended an overall visual angle of 50 degrees x 40 degrees. The mfERGs were summed and analyzed for predetermined retinal loci. These mfERGs were compared with the perimetric findings of the corresponding visual fields. RESULTS: In normal volunteers, the amplitude of the second-order kernel within the central 5 degrees of the nasal hemisphere was significantly smaller than in that of the temporal hemisphere (Wilcoxon signed-rank test, P = 0.0001). In NTG patients, this asymmetry of the two hemispheres was reduced or not present. The ratio of the amplitude of the mfERGs from the nasal and temporal hemispheres (N/T amplitude ratio) in normal control volunteers was significantly different from that of NTG patients with a hemifield defect (analysis of variance, P = 0.0001). When the cutoff value for the N/T amplitude ratio was set at 0.83 for discriminating glaucomatous eyes from normal eyes, the sensitivity was 65.0% with a specificity of 96.7%. The area under the receiver-operating characteristic curve of the N/T amplitude ratio was 0.86. The N/T amplitude ratio and the visual field indices were significantly correlated. CONCLUSION: A decrease in the nasal-temporal asymmetry in the amplitude of the second-order kernel responses within the central 5 degrees of glaucoma patients' eyes indicated a dysfunction of the inner retinal layers, including of the retinal ganglion cells.

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Publishing Authors By Initials

E Asano,K Mochizuki,A Sawada,E Nagasaka,Y Kondo,T Yamamoto,E Asano,K Mochizuki,A Sawada,E Nagasaka,Y Kondo,T Yamamoto,E Asano,K Mochizuki,A Sawada,E Nagasaka,Y Kondo,T Yamamoto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE: 2007 Sep-Oct

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Japanese journal of ophthalmology

VOLUME: 51

Page Numbers: 379-89

Journal Abbreviation: Jpn. J. Ophthalmol.

ISSN: 0021-5155

DAY: 5

MONTH: 10

YEAR: 2007

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 44652

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma.

AFFILIATION: Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Jpn J Ophthalmol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma Related Publications

• CO2-enhanced sonographically guided radiofrequency ablation and transcatheter arterial chemoembolization for small hepatocellular carcinoma poorly defined on conventional sonography.
• Contested dominance modifies the anovulatory consequences of social subordination in female marmosets.
• Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.
• Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002.
• Diastereo- and enantioselective synthesis of nitroso Diels-Alder-type bicycloketones using dienamine: mechanistic insight into sequential nitroso Aldol/Michael reaction and application for optically pure 1-amino-3,4-diol synthesis.
• Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
• Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.
• Effects of bilateral jugular vein ligation on local cerebral blood flow.
• Effects of brain lesions on taste-potentiated odor aversion in rats.
• Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.
• Evaluation of osteogenic/chondrogenic cellular proliferation and differentiation in the xenogeneic periosteal graft.
• Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma.
• Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata.
• Imaging of Regional Differences of Muscle Oxygenation during Exercise Using Spatially Resolved NIRS.
• Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction.
• Intraoperative electro-oculographic Monitoring for Skull Base Surgery.
• Involvement of the Mesolimbic System in Palatability-induced Ingestion.
• Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.
• Kinetic mechanism of the fastest motor protein, Chara myosin.
• Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
• Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
• Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
• Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.
• Regulation of Wnt signalling by receptor-mediated endocytosis.
• Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression.
• The Role of Orexigenic Neuropeptides in the Ingestion of Sweet-tasting Substances in Rats.
• The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology.
• The use of polylactic acid/polyglycolic acid copolymer and gelatin sponge complex containing human recombinant bone morphogenetic protein-2 following condylectomy in rabbits.
• Trehalose Sensitivity of the Gustatory Receptor Neurons Expressing Wild-type, Mutant and Ectopic Gr5a in Drosophila.