Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Abstract Text:

Takahiro Tsukamoto,Koichi Morita,Masanao Naya,Masayuki Inubushi,Chietsugu Katoh,Kenichi Nishijima,Yuji Kuge,Hiroshi Okamoto,Hiroyuki Tsutsui,Nagara Tamaki,Takahiro Tsukamoto,Koichi Morita,Masanao Naya,Masayuki Inubushi,Chietsugu Katoh,Kenichi Nishijima,Yuji Kuge,Hiroshi Okamoto,Hiroyuki Tsutsui,Nagara Tamaki,

Cardiac sympathetic function plays an important role in the regulation of left ventricular (LV) function and the pathophysiology of LV dysfunction. (11)C-CGP-12177 ((11)C-CGP) has been used to assess myocardial beta-adrenergic receptor (beta-AR) density in vivo using PET. The aim of this study is to measure myocardial beta-AR density in patients with nonischemic cardiomyopathy and to compare the measurements with various standard parameters of heart failure (HF), particularly with presynaptic function assessed by (123)I- metaiodobenzylguanidine ((123)I-MIBG) imaging. METHODS: (11)C-CGP PET was performed on 16 patients with nonischemic cardiomyopathy and 8 age-matched healthy volunteers using a double injection method. A (11)C-CGP dynamic scan for 75 min was performed after the injection of (11)C-CGP with a high specific activity. After 30 min, (11)C-CGP with a low specific activity was injected. The beta-AR density of the whole LV was calculated on the basis of the graphical analysis method. Additionally, beta-AR density was compared with LV ejection fraction (LVEF), sympathetic presynaptic function assessed using (123)I-MIBG kinetics, and neurohormonal parameters. RESULTS: The beta-AR density of patients was significantly lower than that of healthy volunteers (3.80 +/- 0.96 vs. 7.70 +/- 1.92 pmol/mL; P < 0.0001). In the patients, beta-AR density correlated significantly with LVEF (r = 0.62, P < 0.05). Furthermore, beta-AR density correlated significantly with the (123)I-MIBG washout rate (r = -0.68, P < 0.01) and delayed heart-to-mediastinum ratio (H/M ratio) (r = 0.61, P < 0.05). On the other hand, the correlation between beta-AR density and early H/M ratio was not significant (r = 0.40, P = 0.13). The beta-AR density of patients with severe HF (New York Heart Association functional [NYHA] class III) was significantly lower than that of those with NYHA functional class I or class II HF (3.24 +/- 0.96 vs. 4.24 +/- 0.73 pmol/mL; P < 0.05). CONCLUSION: A reduction in beta-AR density measured by (11)C-CGP PET was observed in patients with nonischemic cardiomyopathy. This downregulation may be due to the increased presynaptic sympathetic tone as assessed by (123)I-MIBG imaging.

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Publishing Authors By Initials

T Tsukamoto,K Morita,M Naya,M Inubushi,C Katoh,K Nishijima,Y Kuge,H Okamoto,H Tsutsui,N Tamaki,T Tsukamoto,K Morita,M Naya,M Inubushi,C Katoh,K Nishijima,Y Kuge,H Okamoto,H Tsutsui,N Tamaki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 1777-82

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 17

MONTH: 10

YEAR: 2007

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.

AFFILIATION: Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Nucl Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy Related Publications

• A case of milia en plaque successfully treated with oral etretinate.
• Activation of rabbit muscle fructose 1,6-bisphosphatase by histidine and carnosine.
• An unusual manifestation of linear scleroderma 'en coup de sabre' on the vertex and frontoparietal regions.
• Big Mitogen-Activated Protein Kinase 1 (BMK1)/Extracellular Signal Regulated Kinase 5 (ERK5) Is Involved in Platelet-Derived Growth Factor (PDGF)-Induced Vascular Smooth Muscle Cell Migration.
• CD19 expression in B cells is important for suppression of contact hypersensitivity.
• Chemical composition of the wax secreted by a scale insect (Ceroplastes pseudoceriferus Green).
• Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice.
• Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis.
• Construction of a plasmid used for the expression of a sevenfold-mutant barley beta-amylase with increased thermostability in Escherichia coli and properties of the sevenfold-mutant beta-amylase.
• Current opinions and recommendations on multimodal intraoperative monitoring during spine surgeries.
• Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.
• Formation of C14-erythromycin-ribosome complex.
• Glucose-stimulated cAMP-protein kinase a pathway in yeast Saccharomyces cerevisiae.
• Interconversion of the tritium labeled anserine and carosine in rat liver and muscle.
• Isolation of tetradecan-1,14-dioic acid from the comstock mealybug,Pseudococcus comstocki Kuwana (Homoptera: Pseudococcidae).
• Loss of heterozygosity is induced in Candida albicans by ultraviolet irradiation.
• Lymphadenopathy due to amyloidosis secondary to Sjögren syndrome and systemic lupus erythematosus detected by F-18 FDG PET.
• Mechanism of liver tyrosine aminotransferase increase in ethanol-treated mice and its effect on serum tyrosine level.
• Necrobiotic xanthogranuloma with paraproteinemia successfully treated with melphalan, prednisolone and skin graft.
• Predicting key example compounds in competitors' patent applications using structural information alone.
• Recent advances on pathogenesis and therapies in systemic sclerosis.
• Serum chemokine profiles in patients with alopecia areata.
• Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.
• Splenic cysts.
• Treatment of 153 Japanese patients with Q-switched alexandrite laser.
• [Clinical value of 13N-ammonia PET in assessment of cardiac disease: meta-analysis]
• [Evaluation of the product specific standard input function for the IMP-ARG method]
• [Improvement of classroom teaching in medical-surgical nursing]
• [Questions and answers in clinical training. The exchange of student information between teachers and clinical instructors]
• [Training to nurture the attitude necessary in nursing--through analysis of 3 examples from scenes in clinical training]