Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum.

Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Research Abstract Details 

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Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Abstract Text:

Mao-Sheng Hwang,Glenn P Taylor,Robert M Freedom,Mao-Sheng Hwang,Glenn P Taylor,Robert M Freedom,

BACKGROUND: The prognosis for pulmonary atresia and intact ventricular septum (PAIVS) has been poor. Our hypothesis is that intrinsic abnormal left ventricular (LV) intramyocardial circulation might be related to the poor outcomes of these patients. METHODS: Neonatal heart specimens were examined microscopically in four groups of 6 cases each. Group I had PAIVS with ventriculocoronary artery connections (VCAC), group II had PAIVS without VCAC, group III had normal hearts, and group IV had LV hypertrophy. A projection microscope with grid overlay was used to count the LV intramyocardial coronary artery density (IMCAD), which was expressed as the number of profiles/mm(2). RESULTS: The LV IMCAD of groups I (0.40 +/- 0.14/mm(2)) and II (0.45 +/- 0.15/mm(2)) were significantly lower than those of groups III (0.77 +/- 0.11/mm(2)) and IV (0.76 +/- 0.09/mm(2); all with p = 0.002). There was no significant difference between either groups I and II (p = 0.394) or groups III and IV (p = 0.818). CONCLUSIONS: This study demonstrates lower LV IMCAD in a widely heterogeneous spectrum of neonatal hearts with PAIVS, which might potentially predispose these patients to myocardial ischemia and in turn contribute to the poor prognosis of this disease.

Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Publishing Authors By Initials

MS Hwang,GP Taylor,RM Freedom,MS Hwang,GP Taylor,RM Freedom,

For similar cardiovascular diseases: cardiovascular abnormalities: vascular malformations: pulmonary atresia research abstracts see: cardiovascular diseases: cardiovascular abnormalities: vascular malformations: pulmonary atresia research

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Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cardiology

VOLUME: 109

Page Numbers: 10-4

Journal Abbreviation: Cardiology

ISSN: 1421-9751

DAY: 10

MONTH: 07

YEAR: 2007

Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Information

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LANGUAGE: eng

NlmUniqueID: 1266406

Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum. Keywords Mesh Terms:

KEYWORDS: Pulmonary Atresia

MESH TERMS: pathology

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Grant and Affiliation Information for Decreased left ventricular coronary artery density in pulmonary atresia and intact ventricular septum.

AFFILIATION: Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chang Gung Children's Hospital, Taoyuan, Taiwan, ROC.

Country: Switzerland

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MEDLINETA: Cardiology

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