Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer.

Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer. Research Abstract Details 

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Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer. Abstract Text:

Piera Boschetto,Elena Zeni,Lucia Mazzetti,Deborah Miotto,Natalina Lo Cascio,Piero Maestrelli,Emanuela Marian,Patrizia Querzoli,Massimo Pedriali,Bruno Murer,Edoardo De Rosa,Leonardo M Fabbri,Cristina E Mapp,Piera Boschetto,Elena Zeni,Lucia Mazzetti,Deborah Miotto,Natalina Lo Cascio,Piero Maestrelli,Emanuela Marian,Patrizia Querzoli,Massimo Pedriali,Bruno Murer,Edoardo De Rosa,Leonardo M Fabbri,Cristina E Mapp,

Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. Heme-oxygenase (HO)-1, the inducible form of heme-oxygenase, is a cytoprotective enzyme that plays a central role in the defence against oxidative stress and is implicated in the protection of lung tissue against exogenous oxidant exposure. We investigated whether the expression of HO-1 would be decreased in lung tumour as compared with tumour-free adjacent lung tissues. HO-1 expression was quantified by immunohistochemistry in tumour macrophages, in macrophages of tumour-free lung and in tumour cells of surgical specimens collected from 53 individuals with surgically resectable non-small cell lung cancer (NSCLC). The expression of HO-1 was decreased in tumour as compared with tumour-free lung macrophages. No correlations were observed between the expression of HO-1 and both the clinicopathological characteristics and the overall survival of the examined subjects. In conclusion, our data show that macrophages of non-small cell lung cancer exhibit impaired anti-oxidant defence mechanisms, likely mediated by HO-1. Conversely, HO-1 expression does not seem to be associated with lung tumour progression and prognosis.

Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer. Publishing Authors By Initials

P Boschetto,E Zeni,L Mazzetti,D Miotto,NL Cascio,P Maestrelli,E Marian,P Querzoli,M Pedriali,B Murer,E De Rosa,LM Fabbri,CE Mapp,P Boschetto,E Zeni,L Mazzetti,D Miotto,NL Cascio,P Maestrelli,E Marian,P Querzoli,M Pedriali,B Murer,E De Rosa,LM Fabbri,CE Mapp,

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Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Lung cancer (Amsterdam, Netherlands)

VOLUME: 59

Page Numbers: 192-7

Journal Abbreviation: Lung Cancer

ISSN: 0169-5002

DAY: 27

MONTH: 09

YEAR: 2007

Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer. Information

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LANGUAGE: eng

NlmUniqueID: 8800805

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AFFILIATION: Department of Experimental and Clinical Medicine, University of Ferrara, Ferrara, Italy.

Country: Ireland

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MEDLINETA: Lung Cancer

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